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Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells

  • Authors:
    • Ting Zhao
    • Hui Pan
    • Yang Feng
    • Haizhou Li
    • Yang Zhao
  • View Affiliations / Copyright

    Affiliations: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3301-3307
    |
    Published online on: October 3, 2016
       https://doi.org/10.3892/etm.2016.3765
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Abstract

Chenopodium album L. is a common edible herb distributed in China that has been used as a traditional Chinese medicine for antiviral, antifungal, anti‑inflammatory and cancer treatment. However, to the best of our knowledge no previous reports have investigated its the function of its phytochemical extracts in lung cancer cells. The purpose of the present study was to assess the anticancer activities of the phytochemical extracts of C. album L. on human non‑small cell lung cancer A549 cells. The present findings demonstrated that the petroleum ether (PE) extract of C. album L. exhibited significant growth inhibitory effects on A549 with an IC50 value of 33.31±2.79 µg/ml. As determined by MTT and colony formation assays, its growth inhibitory effects were dose‑ and time‑dependent. Furthermore, PE extract‑treated A549 cells exhibited dose‑dependent cell growth arrest at the G1 phase of the cell cycle and cell apoptosis was induced. These results provide useful data on the anticancer activities of C. album L. in human lung cancer and demonstrated the novel possibilities of this plant in developing lung cancer therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao T, Pan H, Feng Y, Li H and Zhao Y: Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells. Exp Ther Med 12: 3301-3307, 2016.
APA
Zhao, T., Pan, H., Feng, Y., Li, H., & Zhao, Y. (2016). Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells. Experimental and Therapeutic Medicine, 12, 3301-3307. https://doi.org/10.3892/etm.2016.3765
MLA
Zhao, T., Pan, H., Feng, Y., Li, H., Zhao, Y."Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells". Experimental and Therapeutic Medicine 12.5 (2016): 3301-3307.
Chicago
Zhao, T., Pan, H., Feng, Y., Li, H., Zhao, Y."Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3301-3307. https://doi.org/10.3892/etm.2016.3765
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao T, Pan H, Feng Y, Li H and Zhao Y: Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells. Exp Ther Med 12: 3301-3307, 2016.
APA
Zhao, T., Pan, H., Feng, Y., Li, H., & Zhao, Y. (2016). Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells. Experimental and Therapeutic Medicine, 12, 3301-3307. https://doi.org/10.3892/etm.2016.3765
MLA
Zhao, T., Pan, H., Feng, Y., Li, H., Zhao, Y."Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells". Experimental and Therapeutic Medicine 12.5 (2016): 3301-3307.
Chicago
Zhao, T., Pan, H., Feng, Y., Li, H., Zhao, Y."Petroleum ether extract of Chenopodium album L. prevents cell growth and induces apoptosis of human lung cancer cells". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3301-3307. https://doi.org/10.3892/etm.2016.3765
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