Pulmonary histoplasmosis in a immunocompetent patient: A case report and literature review

Zhu,Cui; Wang,Ge; Chen,Qiong; He,Bixiu; Wang,Lijing

doi:10.3892/etm.2016.3774

Pulmonary histoplasmosis in a immunocompetent patient: A case report and literature review

Authors:
- Cui Zhu
- Ge Wang
- Qiong Chen
- Bixiu He
- Lijing Wang
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Affiliations: Department of Gerontology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Information and Technology Services, Zhengzhou Maternal and Child Health Hospital, Zhengzhou, Henan 450012, P.R. China
Published online on: October 4, 2016 https://doi.org/10.3892/etm.2016.3774
Pages: 3256-3260
Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, the case of a 54-year-old male patient diagnosed with pulmonary histoplasmosis is reported, with the aim to increase the understanding of the disease characteristics and thereby facilitate the diagnosis and treatment of pulmonary histoplasmosis. Clinical manifestations, diagnosis, treatment and clinical outcomes of the present case of pulmonary histoplasmosis were described. In addition, 76 histoplasmosis patients with complete clinical data were reviewed by searching the literature for relevant studies published during 1990 and 2015. The disease was mainly manifested as cough in the present case, while imaging examination detected a lump shadow in the right lung, accompanied by exudative lesions. Initially, the patient was suspected to have bacterial pneumonia, but subsequently the diagnosis of pulmonary histoplasmosis was confirmed by lung biopsy. The symptoms were alleviated following itraconazole treatment. The patient was physically stable and had no recurrence during the subsequent follow‑up period. In conclusion, pulmonary histoplasmosis is characterized by non‑specific clinical and imaging manifestations, and lung tissue biopsy or respiratory pathogen culture are regarded as the diagnostic gold standards. Individualized antifungal medication should be administered based upon the patients' situation in terms of dosage and duration.

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