Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma

  • Authors:
    • Yunfeng Yi
    • Xiujuan Lu
    • Jianming Chen
    • Changjie Jiao
    • Jing Zhong
    • Zhiming Song
    • Xiaoping Yu
    • Baoli Lin
  • View Affiliations

  • Published online on: October 5, 2016     https://doi.org/10.3892/etm.2016.3783
  • Pages: 3411-3416
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Abstract

microRNAs (miRNAs/miRs) are crucial regulators of gene expression at the post-translational level through promoting mRNA degradation or the repression of translation of target genes. miRs have been confirmed to serve a dominant role in tumor biology. miR-486-5p has been ascertained to be involved in non‑small‑cell lung cancer, breast cancer and hepatocellular carcinoma; however, the expression and function of miR‑486‑5p in esophageal squamous cell carcinoma (ESCC) has yet to be elucidated. The present study aimed to analyze the expression levels of miR‑486‑5p in ESCC tissues and paired normal adjacent tissues, and determine the effects of miR‑486‑5p on esophageal cancer cells using MTT, wound scratch and apoptosis assays. The current results showed that miR‑486‑5p was significantly downregulated in ESCC specimens. Ectopic expression of miR‑486‑5p by synthetic mimics reduced cell proliferation and migration and induced increased cell apoptosis. The results indicated miR‑486‑5p may function as a tumor suppressor in ESCC. The present study demonstrated that miR‑486‑5p was downregulated in ESCC and served a anti‑oncogene role in ESCC via affecting cellular migration.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yi Y, Lu X, Chen J, Jiao C, Zhong J, Song Z, Yu X and Lin B: Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma. Exp Ther Med 12: 3411-3416, 2016.
APA
Yi, Y., Lu, X., Chen, J., Jiao, C., Zhong, J., Song, Z. ... Lin, B. (2016). Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma. Experimental and Therapeutic Medicine, 12, 3411-3416. https://doi.org/10.3892/etm.2016.3783
MLA
Yi, Y., Lu, X., Chen, J., Jiao, C., Zhong, J., Song, Z., Yu, X., Lin, B."Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 12.5 (2016): 3411-3416.
Chicago
Yi, Y., Lu, X., Chen, J., Jiao, C., Zhong, J., Song, Z., Yu, X., Lin, B."Downregulated miR-486-5p acts as a tumor suppressor in esophageal squamous cell carcinoma". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3411-3416. https://doi.org/10.3892/etm.2016.3783