Open Access

Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI

  • Authors:
    • Wenbo Liu
    • Zhipeng Zou
    • Haipeng Jiang
    • Qiang Li
    • Fangming Guo
    • Zhen Wang
    • Hongguang Zhu
  • View Affiliations

  • Published online on: November 18, 2016     https://doi.org/10.3892/etm.2016.3910
  • Pages: 97-102
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the use of preoperative high-dose atorvastatin to prevent the no-reflow phenomenon after percutaneous coronary intervention (PCI). A total of 138 patients with ST‑segment elevation myocardial infarction, admitted from March 2014 to January 2015, were enrolled and randomly divided into 3 groups of 46 individuals each. The groups included a control group in which patients were not treated with atorvastatin before PCI; a conventional‑dose atorvastatin treatment group in which patients received a single dose of 20 mg at bedtime one day prior to PCI; and a high-dose atorvastatin treatment group in which patients were treated with 40 mg divided in two doses the day before PCI. The treatment effects were assessed by re-examining the echocardiography, high-sensitivity C-reactive protein and brain natriuretic peptide (BNP) levels after the PCI. The follow-up examinations included determinations of ultrasound imaging indicators and the contact with patients was maintained for a whole year. The CTFC (frame), pro-BNP, CK-MB peak and WMSI levels of the patients in the high-dose treatment group were significantly lower than those in the conventional dose or the control group. Trombolysis in myocardial infarction ≤2 and myocardial blush grade ≤1 levels were significantly lower than those in the conventional dose group (P=0.01) or those in the control group (P=0.01), although the echocardiographic indicators of the three groups were not significantly different (P<0.05). Nevertheless, it was found that there were significantly fewer adverse cardiovascular events in the high-dose group (P<0.05 in both cases). During the follow-up period, thromboembolism and restenosis were most infrequent in the high-dose atorvastatin group. Based on our findings the oral administration of high-dose atorvastatin before bedtime, one day before the procedure, can effectively prevent no-reflow cases, reduce adverse events and improve the long-term prognosis for acute coronary syndrome patients after PCI.
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January-2017
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Copy and paste a formatted citation
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Spandidos Publications style
Liu W, Zou Z, Jiang H, Li Q, Guo F, Wang Z and Zhu H: Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI. Exp Ther Med 13: 97-102, 2017
APA
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., & Zhu, H. (2017). Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI. Experimental and Therapeutic Medicine, 13, 97-102. https://doi.org/10.3892/etm.2016.3910
MLA
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., Zhu, H."Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI". Experimental and Therapeutic Medicine 13.1 (2017): 97-102.
Chicago
Liu, W., Zou, Z., Jiang, H., Li, Q., Guo, F., Wang, Z., Zhu, H."Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI". Experimental and Therapeutic Medicine 13, no. 1 (2017): 97-102. https://doi.org/10.3892/etm.2016.3910