Iodine‑131 therapy alters the immune/inflammatory responses in the thyroids of patients with Graves' disease

  • Authors:
    • Wenhua Du
    • Qingyu Dong
    • Xiaoting Lu
    • Xiaomeng Liu
    • Yueli Wang
    • Wenxia Li
    • Zhenyu Pan
    • Qian Gong
    • Cuige Liang
    • Guanqi Gao
  • View Affiliations

  • Published online on: January 16, 2017     https://doi.org/10.3892/etm.2017.4047
  • Pages: 1155-1159
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Abstract

The aim of the present study was to evaluate the serum levels of interleukin-6 (IL‑6), CXC chemokine ligand‑10 (CXCL‑10) and intercellular adhesion molecule‑l (ICAM‑1) in patients with Graves' disease (GD) following iodine‑131 (131I) therapy. A total of 30 patients with GD participated in the present study. Serum cytokine levels were measured with ELISA, and correlation analyses were performed. Serum levels of IL‑6, CXCL‑10 and ICAM‑1 were significantly higher in patients with GD prior to treatment than those in the control subjects (P<0.01). Following 131I therapy, the serum levels of IL‑6 and CXCL‑10 in patients with GD were markedly increased within the first week, gradually decreased to the pretreatment level in the subsequent six months and decreased further at 18 months post‑treatment. However, the serum levels of IL‑6 and CXCL‑10 in patients with GD at 18 months following 131I therapy remained significantly higher than in control subjects (P<0.01). Conversely, serum ICAM‑1 levels in patients with GD were gradually increased in the 12 months following 131I therapy and reached a relatively stable level thereafter. Furthermore, the Pearson's correlation analysis indicated that the serum levels of IL‑6, CXCL‑10 and ICAM‑1 were not associated with free triiodothyronine, the free thyroxine index, and thyroid‑stimulating hormone in these patients. 131I therapy was able to alter the immune/inflammatory responses in the thyroids of patients with GD. However, these cytokines (IL‑6, CXCL‑10, and ICAM‑1) are not associated with thyroid function; therefore, they cannot be used as prognostic markers for the 131I therapy of GD.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Du W, Dong Q, Lu X, Liu X, Wang Y, Li W, Pan Z, Gong Q, Liang C, Gao G, Gao G, et al: Iodine‑131 therapy alters the immune/inflammatory responses in the thyroids of patients with Graves' disease. Exp Ther Med 13: 1155-1159, 2017.
APA
Du, W., Dong, Q., Lu, X., Liu, X., Wang, Y., Li, W. ... Gao, G. (2017). Iodine‑131 therapy alters the immune/inflammatory responses in the thyroids of patients with Graves' disease. Experimental and Therapeutic Medicine, 13, 1155-1159. https://doi.org/10.3892/etm.2017.4047
MLA
Du, W., Dong, Q., Lu, X., Liu, X., Wang, Y., Li, W., Pan, Z., Gong, Q., Liang, C., Gao, G."Iodine‑131 therapy alters the immune/inflammatory responses in the thyroids of patients with Graves' disease". Experimental and Therapeutic Medicine 13.3 (2017): 1155-1159.
Chicago
Du, W., Dong, Q., Lu, X., Liu, X., Wang, Y., Li, W., Pan, Z., Gong, Q., Liang, C., Gao, G."Iodine‑131 therapy alters the immune/inflammatory responses in the thyroids of patients with Graves' disease". Experimental and Therapeutic Medicine 13, no. 3 (2017): 1155-1159. https://doi.org/10.3892/etm.2017.4047