Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients

Wang,Ming‑Yu; Wang,Xian‑Bin; Sun,Xue‑Hui; Liu,Feng‑Li; Huang,Sheng‑Chuan

doi:10.3892/etm.2017.4056

Diagnostic value of high-frequency color Doppler ultrasonography examination in combination with anti-cyclic citrullinated peptide antibody testing in rheumatoid arthritis patients

Authors:
- Ming‑Yu Wang
- Xian‑Bin Wang
- Xue‑Hui Sun
- Feng‑Li Liu
- Sheng‑Chuan Huang
View Affiliations

Affiliations: Department of Rheumatology and Immunology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Rheumatology and Radiology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Rheumatology and Ultrasonography, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China
Published online on: January 17, 2017 https://doi.org/10.3892/etm.2017.4056
Pages: 905-908
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

We studied the diagnostic value of high‑frequency color Doppler ultrasonography (HCDU) examination in combination with anti-cyclic citrullinated peptide (anti‑CCP) antibody testing in rheumatoid arthritis (RA) patients with finger joint damage. From January 2015 to December 2015, 80 patients diagnosed with RA with finger joints damage were enrolled in this study. Patients were examined with HCDU. Serum anti‑CCP antibody level was tested using ELISA, and results were compared with the healthy control group. Results obtained by ELISA demonstrated that the positive rate of anti‑CCP antibodies was 73.8% in the study group, and 10% in the control group. The negative rate was 26.2% in the study group, and 90% in the control group. HCDU examination suggested that the predominantly affected joint by bone erosion of RA with finger joint damage was MCP3 (16.7%), followed by PIP3 (14.1%), MCP2 (13.5%) and PIP2 (12.8%). The slightest affected joint was thumb metacarpophalangeal joint, followed by thumb, little finger metacarpophalangeal joint and proximal interphalangeal joint. The sensitivity of diagnosis of RA with finger joints damage with both HCDU and CCP antibody examination showed a significantly lower level compared with examination with each one of the methods alone, while specificity showed a significantly higher level. Thus, a combination of HCDU examination and anti‑CCP antibody testing can be considered useful to improve the early diagnostic rate of RA. HCDU examination is a sensitive, secure, atraumatic and easily‑operated diagnostic method for early RA patients with finger joint damage. When combined with anti‑CCP antibody testing, it will provide a better chance for RA patients, and give them hope for a better treatment and improved prognosis.

View Figures

View References

1	Botar-Jid C, Bolboaca S, Fodor D, Bocsa C, Tamas MM, Micu M, Dudea SM, Vasilescu D and Badea R: Gray scale and power Doppler ultrasonography in evaluation of early rheumatoid arthritis. Med Ultrason. 12:300–305. 2010.PubMed/NCBI
2	Ceccarelli F, Perricone C, Fabris M, Alessandri C, Iagnocco A, Fabro C, Pontarini E, De Vita S and Valesini G: Transforming growth factor β 869C/T and interleukin 6 −174G/C polymorphisms relate to the severity and progression of bone-erosive damage detected by ultrasound in rheumatoid arthritis. Arthritis Res Ther. 13:R1112011. View Article : Google Scholar : PubMed/NCBI
3	Rizzo C, Ceccarelli F, Gattamelata A, Vavala C, Valesini G and Iagnocco A: Ultrasound in rheumatoid arthritis. Med Ultrason. 15:199–208. 2013. View Article : Google Scholar : PubMed/NCBI
4	Hsu HJ, Yang YH, Shieh TY, Chen CH, Kao YH, Yang CF and Ko EC: Role of cytokine gene (interferon-γ, transforming growth factor-β1, tumor necrosis factor-α, interleukin-6, and interleukin-10) polymorphisms in the risk of oral precancerous lesions in Taiwanese. Kaohsiung J Med Sci. 30:551–558. 2014. View Article : Google Scholar : PubMed/NCBI
5	Orguc S, Tikiz C, Aslanalp Z and Erbay PD: Comparison of OMERACT-RAMRIS scores and computer-aided dynamic magnetic resonance imaging findings of hand and wrist as a measure of activity in rheumatoid arthritis. Rheumatol Int. 33:1837–1844. 2013. View Article : Google Scholar : PubMed/NCBI
6	Yang H, Rivoire J, Hoppe M, Srikhum W, Imboden J, Link TM and Li X: Computer-aided and manual quantifications of MRI synovitis, bone marrow edema-like lesions, erosion and cartilage loss in rheumatoid arthritis of the wrist. Skeletal Radiol. 44:539–547. 2015. View Article : Google Scholar : PubMed/NCBI
7	Tamai M, Kawakami A, Iwamoto N, Kawashiri SY, Fujikawa K, Aramaki T, Kita J, Okada A, Koga T, Arima K, et al: Comparative study of the detection of joint injury in early-stage rheumatoid arthritis by magnetic resonance imaging of the wrist and finger joints and physical examination. Arthritis Care Res (Hoboken). 63:436–439. 2011.PubMed/NCBI
8	Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB and Li X: Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: A multimodality study. J Rheumatol. 41:1766–1773. 2014. View Article : Google Scholar : PubMed/NCBI
9	Carter JD, Patelli M, Anderson SR, Prakash N, Rodriquez EJ, Bateman H, Sterrett A, Valeriano J and Ricca LR: An MRI assessment of chronic synovial-based inflammation in gout and its correlation with serum urate levels. Clin Rheumatol. 34:345–351. 2015. View Article : Google Scholar : PubMed/NCBI
10	Feehan L, Buie H, Li L and McKay H: A customized protocol to assess bone quality in the metacarpal head, metacarpal shaft and distal radius: a high resolution peripheral quantitative computed tomography precision study. BMC Musculoskelet Disord. 14:3672013. View Article : Google Scholar : PubMed/NCBI
11	Bensaoud N, Rostom S, Bahiri R and Hajjaj-Hassouni N: Efficacy of tocilizumab on MRI-determined bone oedema in rheumatoid arthritis. Clin Rheumatol. 34:1031–1037. 2015. View Article : Google Scholar : PubMed/NCBI
12	Yu JI, Park YR, Lee SS and Chae SC: Polymorphisms of interleukin-31 are associated with anti-CCP levels in females with rheumatoid arthritis. J Genet. 93:813–817. 2014. View Article : Google Scholar : PubMed/NCBI
13	Yousefghahari B, Alhooei S, Soleimani-Amiri MJ and Guran A: Comparison of sensitivity and specificity of anti-CCP and anti-MCV antibodies in an Iranian cohort of patients with rheumatoid arthritis. Caspian J Intern Med. 4:702–706. 2013.PubMed/NCBI
14	Arkfeld DG: Biological significance of anti-cyclic citrullinated peptide antibody in rheumatoid arthritis. Ann Intern Med. 148:403–404; author reply 403–404. 2008. View Article : Google Scholar : PubMed/NCBI
15	Alexiou I, Germenis A, Ziogas A, Theodoridou K and Sakkas LI: Diagnostic value of anti-cyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis. BMC Musculoskelet Disord. 8:372007. View Article : Google Scholar : PubMed/NCBI
16	Moghimi J, Ghorbani R, Hasani F and Sheikhvatan M: Discriminative and diagnostic value of anti-cyclic citrullinated peptide antibodies in Iranian patients with rheumatoid arthritis. Rheumatol Int. 33:601–605. 2013. View Article : Google Scholar : PubMed/NCBI
17	Yang DH, Tu CC, Wang SC, Wei CC and Cheng YW: Circulating anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis and chronic obstructive pulmonary disease. Rheumatol Int. 34:971–977. 2014. View Article : Google Scholar : PubMed/NCBI
18	Perez-Alamino R, Garcia-Valladares I, Cuchacovich R, Iglesias-Gamarra A and Espinoza LR: Are anti-CCP antibodies in psoriatic arthritis patients a biomarker of erosive disease? Rheumatol Int. 34:1211–1216. 2014. View Article : Google Scholar : PubMed/NCBI
19	Vlad V, Berghea F, Libianu S, Balanescu A, Bojinca V, Constantinescu C, Abobului M, Predeteanu D and Ionescu R: Ultrasound in rheumatoid arthritis: volar versus dorsal synovitis evaluation and scoring. BMC Musculoskelet Disord. 12:1242011. View Article : Google Scholar : PubMed/NCBI
20	Kroot EJ, de Jong BA, van Leeuwen MA, Swinkels H, van den Hoogen FH, van't Hof M, van de Putte LB, van Rijswijk MH, van Venrooij WJ and van Riel PL: The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 43:1831–1835. 2000. View Article : Google Scholar : PubMed/NCBI
21	Bas S, Perneger TV, Seitz M, Tiercy JM, Roux-Lombard P and Guerne PA: Diagnostic tests for rheumatoid arthritis: Comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors. Rheumatology (Oxford). 41:809–814. 2002. View Article : Google Scholar : PubMed/NCBI