Morphine and pregabalin in the treatment of neuropathic pain

Wang,Yue; Yang,Helen; Shen,Chunjian; Luo,Ji

doi:10.3892/etm.2017.4102

Morphine and pregabalin in the treatment of neuropathic pain

Authors:
- Yue Wang
- Helen Yang
- Chunjian Shen
- Ji Luo
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Affiliations: Department of General Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China, Institute of Public Health, University of California, San Francisco, CA 94117‑1080, USA, Department of General Surgery, The Second Hospital of Shenyang Medical College, Shenyang, Liaoning 110000, P.R. China, Department of General Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
Published online on: February 7, 2017 https://doi.org/10.3892/etm.2017.4102
Pages: 1393-1397
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The drugs that are currently available to treat neuropathic pain exhibit inadequate efficacy and numerous adverse effects. The present study compared the efficacy of combination therapy with pregabalin and morphine with that of each as a single agent in patients with neuropathic pain. The primary measurement was mean daily pain intensity. Secondary measurements included a pain questionnaire, adverse effects, mood and quality of life. Combination therapy of morphine plus pregabalin and morphine monotherapy were both more effective at reducing neuropathic pain than pregabalin monotherapy. Furthermore, patients in the combination group noted that their quality of life markedly improved from the baseline, as compared with the patients in the other two groups. These findings indicate that combination therapy with morphine and pregabalin may be used as a valuable therapy for neuropathic pain.

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