Factors affecting the accuracy and safety of computed tomography-guided biopsy of intrapulmonary solitary nodules ≤30 mm in a retrospective study of 155 patients

  • Authors:
    • Gang Zhao
    • Xiaobao Shi
    • Wei Sun
    • Hongyuan Liang
    • Xiaonan Mao
    • Feng Wen
    • Ming Shan
    • Xihai Wang
    • Zaiming Lu
  • View Affiliations

  • Published online on: March 2, 2017     https://doi.org/10.3892/etm.2017.4179
  • Pages: 1986-1992
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Abstract

Computed tomography (CT)-guided percutaneous fine needle biopsy is a common method for lung biopsy. The objective of this study was to investigate factors affecting the accuracy and safety of CT-guided percutaneous lung biopsy of nodules ≤30 mm in diameter. Between January 2013 and March 2014, 155 patients underwent a CT‑guided percutaneous biopsy procedure on an intrapulmonary solitary nodule measuring ≤30 mm in diameter. Prospectively collected data were retrospectively reviewed and examined for the influence of clinical and pathological characteristics (age, gender, smoking status, adhesion of nodule to the pleura, puncture depth, nodule size and time of biopsy) on the accuracy of biopsy and incidence of pneumothorax and hemorrhage. The accuracy of CT‑guided biopsy was 90.3% (140/155). Biopsies predominantly contained lung adenocarcinoma (114/140; 81.4%) or squamous cell carcinoma of the lung (10/140; 7.1%). Accuracy was significantly dependent on nodule size, ranging in accuracy from 85 to 97% for patients with nodule diameters of ≤20 or 21‑30 mm, respectively (P<0.05). Pleural adherence of the nodule significantly increased the accuracy of the biopsy (P<0.05). Patients with a nodule of 11‑20 mm in diameter had a significantly higher incidence of pneumothorax compared with patients with a smaller nodule (P=0.013). In conclusion, the nodule size and adhesion to the pleura influenced the accuracy of CT‑guided biopsy of intrapulmonary nodules that were ≤30 mm in diameter. Nodule size may also affect the incidence of severe complications. CT-guided percutaneous lung biopsy has a high accuracy and is easy and safe to conduct for intrapulmonary solitary nodules of ≤30 mm in diameter.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhao G, Shi X, Sun W, Liang H, Mao X, Wen F, Shan M, Wang X and Lu Z: Factors affecting the accuracy and safety of computed tomography-guided biopsy of intrapulmonary solitary nodules ≤30 mm in a retrospective study of 155 patients. Exp Ther Med 13: 1986-1992, 2017.
APA
Zhao, G., Shi, X., Sun, W., Liang, H., Mao, X., Wen, F. ... Lu, Z. (2017). Factors affecting the accuracy and safety of computed tomography-guided biopsy of intrapulmonary solitary nodules ≤30 mm in a retrospective study of 155 patients. Experimental and Therapeutic Medicine, 13, 1986-1992. https://doi.org/10.3892/etm.2017.4179
MLA
Zhao, G., Shi, X., Sun, W., Liang, H., Mao, X., Wen, F., Shan, M., Wang, X., Lu, Z."Factors affecting the accuracy and safety of computed tomography-guided biopsy of intrapulmonary solitary nodules ≤30 mm in a retrospective study of 155 patients". Experimental and Therapeutic Medicine 13.5 (2017): 1986-1992.
Chicago
Zhao, G., Shi, X., Sun, W., Liang, H., Mao, X., Wen, F., Shan, M., Wang, X., Lu, Z."Factors affecting the accuracy and safety of computed tomography-guided biopsy of intrapulmonary solitary nodules ≤30 mm in a retrospective study of 155 patients". Experimental and Therapeutic Medicine 13, no. 5 (2017): 1986-1992. https://doi.org/10.3892/etm.2017.4179