Hemophagocytic lymphohistiocytosis in a patient with human immunodeficiency virus infection: A case report

Nie,Yijun; Zhang,Zhanglin; Wu,Hong; Wan,Lagen

doi:10.3892/etm.2017.4241

Hemophagocytic lymphohistiocytosis in a patient with human immunodeficiency virus infection: A case report

Authors:
- Yijun Nie
- Zhanglin Zhang
- Hong Wu
- Lagen Wan
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Affiliations: Department of Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Institute of Blood Transfusion, Jiangxi Province Blood Center, Nanchang, Jiangxi 330052, P.R. China
Published online on: March 20, 2017 https://doi.org/10.3892/etm.2017.4241
Pages: 2480-2482

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Abstract

Hemophagocytic lymphohistiocytosis (HLH), also termed hemophagocytic syndrome, is a severe, life-threatening inflammatory condition that results from an excessive, prolonged and ineffective immune response. The syndrome occurs due to overactive macrophages from the bone marrow or lymph tissue that phagocytose erythrocytes leukocytes and platelets. HLH in a patient with human immunodeficiency virus infection has rarely been studied. The present case study described an uncommon case of this syndrome in combination with human immunodeficiency virus infection in a patient, who eventually succumbed to severe infection and multiple organ failure following the refusal of medical treatment.

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1	Janka GE and Lehmberg K: Hemophagocytic lymphohistiocytosis: Pathogenesis and treatment. Hematology Am Soc Hematol Educ Program. 2013:605–611. 2013.PubMed/NCBI
2	Campo M and Berliner N: Hemophagocytic Lymphohistiocytosis in adults. Hematol Oncol Clin North Am. 29:915–925. 2015. View Article : Google Scholar : PubMed/NCBI
3	Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J and Janka G: HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 48:124–131. 2007. View Article : Google Scholar : PubMed/NCBI
4	Janka GE and Lehmberg K: Hemophagocytic syndromes-an update. Blood Rev. 28:135–142. 2014. View Article : Google Scholar : PubMed/NCBI
5	Malinowska I, Machaczka M, Popko K, Siwicka A, Salamonowicz M and Nasiłowska-Adamska B: Hemophagocytic syndrome in children and adults. Arch Immunol Ther Exp (Warsz). 62:385–394. 2014. View Article : Google Scholar : PubMed/NCBI
6	Lehmberg K, Albert MH, Beier R, Beutel K, Gruhn B, Kröger N, Meisel R, Schulz A, Stachel D, Woessmann W, et al: Treosulfan-based conditioning regimen for children and adolescents with hemophagocytic lymphohistiocytosis. Haematologica. 99:180–184. 2014. View Article : Google Scholar : PubMed/NCBI
7	Lehmberg K, Nichols KE, Henter JI, Girschikofsky M, Greenwood T, Jordan M, Kumar A, Minkov M, La Rosée P, Weitzman S, et al: Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies. Haematologica. 100:997–1004. 2015.PubMed/NCBI
8	Adachi E, Koibuchi T, Imai K, Kikuchi T, Shimizu S, Koga M, Nakamura H, Iwamoto A and Fujii T: Hemophagocytic syndrome in an acute human immunodeficiency virus infection. Intern Med. 52:629–632. 2013. View Article : Google Scholar : PubMed/NCBI
9	Meki A, O'Connor D, Roberts C and Murray J: Hemophagocytic lymphohistiocytosis in chronic lymphocytic leukemia. J Clin Oncol. 29:e685–e687. 2011. View Article : Google Scholar : PubMed/NCBI
10	Usman M, Thapa SD, Hadid H and Yessayan LT: HIV infection presenting proliferation of CD8+ T lymphocyte and hemophagocytic lymphohistiocytosis. Int J STD AIDS. 27:411–413. 2016. View Article : Google Scholar : PubMed/NCBI
11	Uemura M, Huynh R, Kuo A, Antelo F, Deiss R and Yeh J: Hemophagocytic Lymphohistiocytosis complicating T-cell lymphoma in a patient with HIV infection. Case Rep Hematol. 2013:6872602013.PubMed/NCBI
12	Tothova Z and Berliner N: Hemophagocytic syndrome and critical Illness: New insights into diagnosis and management. J Intensive Care Med. 30:401–412. 2015. View Article : Google Scholar : PubMed/NCBI
13	Rouphael NG, Talati NJ, Vaughan C, Cunningham K, Moreira R and Gould C: Infections associated with haemophagocytic syndrome. Lancet Infect Dis. 7:814–822. 2007. View Article : Google Scholar : PubMed/NCBI
14	Janka G: Hemophagocytic lymphohistiocytosis: When the immune system runs amok. Klin Padiatr. 221:278–285. 2009. View Article : Google Scholar : PubMed/NCBI