Effects of negative-pressure wound therapy combined with microplasma on treating wounds of ulcer and the expression of heat shock protein 90

Li,Zhihong; Wang,Qihong; Mi,Wenxin; Han,Mei; Gao,Fei; Niu,Guangyan; Ma,Yindong

doi:10.3892/etm.2017.4266

Effects of negative-pressure wound therapy combined with microplasma on treating wounds of ulcer and the expression of heat shock protein 90

Authors:
- Zhihong Li
- Qihong Wang
- Wenxin Mi
- Mei Han
- Fei Gao
- Guangyan Niu
- Yindong Ma
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Affiliations: Department of Burns Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China
Published online on: March 27, 2017 https://doi.org/10.3892/etm.2017.4266
Pages: 2211-2216
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effects of negative pressure wound therapy (NPWT) combined with microplasma on treating wounds of ulcer, and blood perfusion of wound-healing of interface, angiogenesis and the expressions of heat shock protein 90 (HSP90) were explored. We selected continuously 64 patients with wounds of ulcer. The patients were divided into the conventional treatment group (just medical foam dressing and 1% silver sulfadiazine cream for dressing changes) (n=20 cases), the NPWT group (n=22 cases) and the combination group (NPWT combined with microplasma) (n=22 cases), and compared the effects. It was found that in the 7 and 14 day combination group, maturity of granulation tissues and growth degree of epithelium were significantly higher than those in other two groups, and the areas of ulcer reduced significantly, the healing rate increased significantly (P<0.05). In the 7 and 14 day combination group, blood perfusion of wounds and density of new vessels were significantly higher than the other two groups (P<0.05). In the 7 and 14 day combination group, the expression of HSP90 was significantly higher than the other two groups (P<0.05). In conclusion, NPWT combined with microplasma can improve the healing of woulds of ulcers, and it is related to the upregulated expression of HSP90.

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