Open Access

Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients

  • Authors:
    • Yuqiang Sun
    • Xiaofeng Wang
    • Ningwei Che
    • Huamin Qin
    • Shuping Liu
    • Xinling Wu
    • Minghai Wei
    • Huakun Cheng
    • Jian Yin
  • View Affiliations

  • Published online on: April 6, 2017     https://doi.org/10.3892/etm.2017.4315
  • Pages: 2225-2234
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the effects of surgical intervention of focal cortical dysplasia (FCD) IIa on the outcome of epilepsy, and to evaluate the prognostic factors of seizure freedom. Patient data from epilepsy surgeries were retrospectively reviewed at the Second Affiliated Hospital of Dalian Medical University between 2007 and 2015. A total of 110 patients with a definite pathological diagnosis of FCD IIa were included. Moreover, the clinical characteristics, seizure outcome and quality of life in adults with FCD IIa were evaluated. The Engel seizure outcome achievements were class I in 72, class II in 20, class III in 11 and class IV in 7 patients. In addition, the Engel seizure outcome was relevant with the resection range of the lesions (P=0.028). The assessments of electrocorticography (ECoG) patterns and magnetic resonance imaging (MRI) are relevant to determining the extent of the resection, which may influence the surgery outcome (P=0.001 and P=0.023). Using multivariate regression analyses, the extent of resection, seizure frequency, preoperative ECoG and location of resection were the most important risk factors for seizure recurrence. The results of quality of life in epilepsy‑10 scoring revealed that the quality of life improved significantly following surgery (P<0.01). Moreover, surgical intervention, EcoG, MRI positioning and complete resection helped to have improved seizure control, relief of anxiety and quality of life. All these observations strongly recommend an early consideration of epilepsy surgery in FCD IIa patients.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Sun Y, Wang X, Che N, Qin H, Liu S, Wu X, Wei M, Cheng H and Yin J: Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients. Exp Ther Med 13: 2225-2234, 2017.
APA
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X. ... Yin, J. (2017). Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients. Experimental and Therapeutic Medicine, 13, 2225-2234. https://doi.org/10.3892/etm.2017.4315
MLA
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X., Wei, M., Cheng, H., Yin, J."Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients". Experimental and Therapeutic Medicine 13.5 (2017): 2225-2234.
Chicago
Sun, Y., Wang, X., Che, N., Qin, H., Liu, S., Wu, X., Wei, M., Cheng, H., Yin, J."Clinical characteristics and epilepsy outcomes following surgery caused by focal cortical dysplasia (type IIa) in 110 adult epileptic patients". Experimental and Therapeutic Medicine 13, no. 5 (2017): 2225-2234. https://doi.org/10.3892/etm.2017.4315