Open Access

Dietary soy isoflavones alleviate dextran sulfate sodium‑induced inflammation and oxidative stress in mice

  • Authors:
    • Bin Wang
    • Cunbing Wu
  • View Affiliations

  • Published online on: May 18, 2017     https://doi.org/10.3892/etm.2017.4469
  • Pages: 276-282
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been hypothesized that soy isoflavones exhibit anti-oxidative and anti‑inflammatory functions, however, the effects of soy isoflavones on inflammatory bowel diseases remain unknown. Therefore, the present study aimed to investigate the effect and underlying mechanism of dietary soy isoflavones on dextran sulfate sodium (DSS)‑induced colitis. Mice were administered DSS and soy isoflavones, and histomorphometry, oxidative stress, inflammation and intestinal tight junctions were determined. The current study demonstrated that dietary soy isoflavones alleviated DSS‑induced growth suppression, colonic inflammatory response, oxidative stress and colonic barrier dysfunction. DSS treatment was indicated to activate Toll‑like receptor 4 (TRL4) and myeloid differentiation protein 88 (MyD88) in mice, whereas dietary soy isoflavones inhibited Myd88 expression in DSS‑challenged mice. In conclusion, dietary soy isoflavones alleviate DSS‑induced inflammation in mice, which may be associated with enhancing antioxidant function and inhibiting the TLR4/MyD88 signal.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang B and Wu C: Dietary soy isoflavones alleviate dextran sulfate sodium‑induced inflammation and oxidative stress in mice. Exp Ther Med 14: 276-282, 2017.
APA
Wang, B., & Wu, C. (2017). Dietary soy isoflavones alleviate dextran sulfate sodium‑induced inflammation and oxidative stress in mice. Experimental and Therapeutic Medicine, 14, 276-282. https://doi.org/10.3892/etm.2017.4469
MLA
Wang, B., Wu, C."Dietary soy isoflavones alleviate dextran sulfate sodium‑induced inflammation and oxidative stress in mice". Experimental and Therapeutic Medicine 14.1 (2017): 276-282.
Chicago
Wang, B., Wu, C."Dietary soy isoflavones alleviate dextran sulfate sodium‑induced inflammation and oxidative stress in mice". Experimental and Therapeutic Medicine 14, no. 1 (2017): 276-282. https://doi.org/10.3892/etm.2017.4469