Open Access

miRNAs in vascular integrity (Review)

  • Authors:
    • Yong Cao
    • Pei-Ying Zhang
  • View Affiliations

  • Published online on: May 25, 2017     https://doi.org/10.3892/etm.2017.4515
  • Pages: 473-477
  • Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Endothelial cells (ECs) are confirmed as important regulators of vascular integrity, particularly in relation to angiogenesis, wound repair post-injury, and during embryogenesis. Futher, miRNAs have been implicated in EC function and proliferation. Moreover, knockdown of these miRNAs resulted in altered expressions of several important regulators of endothelial biology and angiogenesis including vascular endothelial growth factor receptor 2, endothelial nitric oxide synthase and tubule formation capacity. Several miRNAs have been identified to play a role in the regulation of function, proliferation and growth of vascular ECs. These miRNAs may be important therapeutic targets in the treatment of a range of ischemic diseases, as well as in the regulation of angiogenesis during cancer and tumour progression. The present review discuss some of the important miRNAs having confirmed regulatory role in EC in connection espically with cardiovascular disease.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Cao Y and Zhang P: miRNAs in vascular integrity (Review). Exp Ther Med 14: 473-477, 2017.
APA
Cao, Y., & Zhang, P. (2017). miRNAs in vascular integrity (Review). Experimental and Therapeutic Medicine, 14, 473-477. https://doi.org/10.3892/etm.2017.4515
MLA
Cao, Y., Zhang, P."miRNAs in vascular integrity (Review)". Experimental and Therapeutic Medicine 14.1 (2017): 473-477.
Chicago
Cao, Y., Zhang, P."miRNAs in vascular integrity (Review)". Experimental and Therapeutic Medicine 14, no. 1 (2017): 473-477. https://doi.org/10.3892/etm.2017.4515