The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors (Review)

  • Authors:
    • Hengdao Liu
    • Dan Lin
    • Hong Xiang
    • Wei Chen
    • Shaoli Zhao
    • Hui Peng
    • Jie Yang
    • Pan Chen
    • Shuhua Chen
    • Hongwei Lu
  • View Affiliations

  • Published online on: June 14, 2017     https://doi.org/10.3892/etm.2017.4600
  • Pages: 891-897
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Abstract

At present, it is commonly accepted that atherosclerosis is a chronic inflammatory disease characterized by disorder of the arterial wall. As one of the inflammatory cytokines of the tumor necrosis factor superfamily, tumor necrosis factor‑like weak inducer of apoptosis (TWEAK) participates in the formation and progression of atherosclerosis. TWEAK, when binding to its initial receptor, fibroblast growth factor inducible molecule 14 (Fn14), exerts adverse biological functions in atherosclerosis, including dysfunction of endothelial cells, phenotypic change of smooth muscle cells and inflammatory responses of monocytes/macrophages. However, accumulating data supports that, besides Fn14, TWEAK also binds to cluster of differentiation (CD)163, an anti‑inflammatory cytokine and a scavenger receptor exclusively expressed by monocytes and macrophages. Furthermore, it has been demonstrated that CD163 is able to internalize TWEAK and likely elicits protective effects in atherosclerosis by terminating inflammation induced by TWEAK. In the present study, the role of TWEAK in atherosclerosis was reviewed, with a predominant focus on CD163 and Fn14 receptors.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu H, Lin D, Xiang H, Chen W, Zhao S, Peng H, Yang J, Chen P, Chen S, Lu H, Lu H, et al: The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors (Review). Exp Ther Med 14: 891-897, 2017
APA
Liu, H., Lin, D., Xiang, H., Chen, W., Zhao, S., Peng, H. ... Lu, H. (2017). The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors (Review). Experimental and Therapeutic Medicine, 14, 891-897. https://doi.org/10.3892/etm.2017.4600
MLA
Liu, H., Lin, D., Xiang, H., Chen, W., Zhao, S., Peng, H., Yang, J., Chen, P., Chen, S., Lu, H."The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors (Review)". Experimental and Therapeutic Medicine 14.2 (2017): 891-897.
Chicago
Liu, H., Lin, D., Xiang, H., Chen, W., Zhao, S., Peng, H., Yang, J., Chen, P., Chen, S., Lu, H."The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors (Review)". Experimental and Therapeutic Medicine 14, no. 2 (2017): 891-897. https://doi.org/10.3892/etm.2017.4600