Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans

  • Authors:
    • Ying Liang
    • Qinying Cao
    • Xing Gao
    • Huilan Du
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  • Published online on: June 14, 2017     https://doi.org/10.3892/etm.2017.4603
  • Pages: 1171-1176
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Abstract

Bone morphogenetic protein-6 (BMP-6), which is a member of the transforming growth factor‑β superfamily, is associated with the regulation of bone development and various physiological processes. In the present study, the expression of BMP‑6 in follicular fluid and granulosa cells (GCs) from pregnant and non‑pregnant patients was explored. A total of 44 pregnant patients (pregnant group) and 36 non-pregnant patients (non‑pregnant group) were recruited for the present study. The expression of BMP‑6 was detected using western blotting and reverse transcription‑quantitative polymerase chain reaction. The expression of BMP‑6 was significantly higher at the protein level (P<0.01) in follicular fluid obtained from the pregnant group compared with that from the non‑pregnant group. The mRNA and protein expression of BMP‑6 in GCs were significantly upregulated in the pregnant group compared with the non‑pregnant group (both P<0.01). These results suggest that high expression of BMP‑6 in pregnant women may be a novel biomarker for the fertility process.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liang Y, Cao Q, Gao X and Du H: Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans. Exp Ther Med 14: 1171-1176, 2017
APA
Liang, Y., Cao, Q., Gao, X., & Du, H. (2017). Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans. Experimental and Therapeutic Medicine, 14, 1171-1176. https://doi.org/10.3892/etm.2017.4603
MLA
Liang, Y., Cao, Q., Gao, X., Du, H."Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans". Experimental and Therapeutic Medicine 14.2 (2017): 1171-1176.
Chicago
Liang, Y., Cao, Q., Gao, X., Du, H."Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1171-1176. https://doi.org/10.3892/etm.2017.4603