Open Access

Electroacupuncture promotes axonal regeneration in rats with focal cerebral ischemia through the downregulation of Nogo-A/NgR/RhoA/ROCK signaling

  • Authors:
    • Saie Huang
    • Danxia Huang
    • Jiapei Zhao
    • Lidian Chen
  • View Affiliations

  • Published online on: June 16, 2017     https://doi.org/10.3892/etm.2017.4621
  • Pages: 905-912
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The purpose of the present study was to evaluate the effect of electroacupuncture (EA) on the axonal regeneration environment following cerebral ischemia injury and to investigate whether it was associated with Nogo‑A/Nogo receptor (NgR)/RhoA/Rho‑associated protein kinase (ROCK) signaling. Using a rat model of focal cerebral ischemia, the effects of EA at the Quchi (LI11) and Zusanli (ST36) acupoints on axonal growth inhibitory protein and axonal growth factors were assessed and the underlying molecular mechanisms were investigated. It was found that EA at the Quchi and Zusanli acupoints significantly improved neurological deficit scores following ischemia (P<0.05), and reduced the cerebral infarct volume. Moreover, it was demonstrated that crucial signaling molecules in the Nogo‑A signaling pathway were regulated by EA. These results suggest that EA provides a less inhibitory environment for axonal regeneration following cerebral ischemia through inhibition of Nogo‑A/NgR/RhoA/ROCK signaling.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Huang S, Huang D, Zhao J and Chen L: Electroacupuncture promotes axonal regeneration in rats with focal cerebral ischemia through the downregulation of Nogo-A/NgR/RhoA/ROCK signaling. Exp Ther Med 14: 905-912, 2017
APA
Huang, S., Huang, D., Zhao, J., & Chen, L. (2017). Electroacupuncture promotes axonal regeneration in rats with focal cerebral ischemia through the downregulation of Nogo-A/NgR/RhoA/ROCK signaling. Experimental and Therapeutic Medicine, 14, 905-912. https://doi.org/10.3892/etm.2017.4621
MLA
Huang, S., Huang, D., Zhao, J., Chen, L."Electroacupuncture promotes axonal regeneration in rats with focal cerebral ischemia through the downregulation of Nogo-A/NgR/RhoA/ROCK signaling". Experimental and Therapeutic Medicine 14.2 (2017): 905-912.
Chicago
Huang, S., Huang, D., Zhao, J., Chen, L."Electroacupuncture promotes axonal regeneration in rats with focal cerebral ischemia through the downregulation of Nogo-A/NgR/RhoA/ROCK signaling". Experimental and Therapeutic Medicine 14, no. 2 (2017): 905-912. https://doi.org/10.3892/etm.2017.4621