Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis

Liu,Yifei; Yao,Xiufang; Zhang,Qing; Qian,Li; Feng,Jia; Bian,Tingting; Zhang,Jianguo; Tian,Ye

doi:10.3892/etm.2017.4632

Expression of Kruppel‑like factor 8 and Ki67 in lung adenocarcinoma and prognosis

Authors:
- Yifei Liu
- Xiufang Yao
- Qing Zhang
- Li Qian
- Jia Feng
- Tingting Bian
- Jianguo Zhang
- Ye Tian
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Affiliations: Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China, Department of Pathology, The First People's Hospital of Rudong, Nantong, Jiangsu 226401, P.R. China, Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
Published online on: June 20, 2017 https://doi.org/10.3892/etm.2017.4632
Pages: 1351-1356
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Kruppel‑like factor 8 (KLF8) belongs to the KLF family and has various roles in the regulation of the cell cycle, proliferation and tumor genesis. KLF8 is overexpressed in gastric, ovarian, breast and renal cancer. Additionally, KLF8 may affect invasion and metastasis of tumors. However, whether KLF8 also acts as an ontogeny in lung adenocarcinoma (LAC) remains unknown. The aim of the present study was to determine the association between KLF8 expression and various clinical and pathological parameters. Western blot assays and immune histochemistry analyses revealed that KLF8 level in LAC tissues was higher than that in the normal lung tissues and KLF8 expression was significantly associated with clinical variables (P<0.05). Kaplan‑Meier curves revealed that high expression of KLF8 was related to poor prognosis in patients with LAC. The present study also demonstrated that KLF8 was involved in the progression of lung adenocarcinoma. This data suggested that KLF8 may act as a prognostic factor in lung adenocarcinoma progression.

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