Open Access

Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury

  • Authors:
    • Jian Ding
    • Xin Niu
    • Yan Su
    • Xiaolin Li
  • View Affiliations

  • Published online on: June 21, 2017     https://doi.org/10.3892/etm.2017.4636
  • Pages: 1609-1613
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, the levels of synovial fluid biomarkers of patients with knee osteoarthritis (OA) and those with meniscus injury (MI) were compared to associate the levels of synovial fluid biomarkers with the degree of OA and MI. Synovial fluid samples were obtained from 51 cases with OA and 40 patients with MI. Severity of OA and MI were evaluated using the Kellgren-Lawrence (K-L) classification and Magnetic Resonance Imaging Osteoarthritis Knee Score, respectively. A comparative analysis of the levels of matrix metalloproteinase-13 (MMP-13), vascular endothelial growth factor (VEGF), interleukin (IL)-10, IL-8, IL-6, IL-1, tumor necrosis factor-α (TNF-α), as well as collagenase 2 in synovial fluid was made between patients with OA and MI. We found that synovial fluid levels of VEGF and IL-6 were significantly higher in patients with OA than in patients with MI, and IL-10 was lower in patients with OA compared to MI patients (p<0.05). After adjusting for sex, course of disease, and surgical history, no significant associations between K-L scores and biomarker levels were found for patients with OA. In the MI patients, TNF-α was significantly associated with magnetic resonance imaging (MRI) score. In conclusion, patients with knee OA and MI have different patterns of biomarker expression in their synovial fluid.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ding J, Niu X, Su Y and Li X: Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury. Exp Ther Med 14: 1609-1613, 2017
APA
Ding, J., Niu, X., Su, Y., & Li, X. (2017). Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury. Experimental and Therapeutic Medicine, 14, 1609-1613. https://doi.org/10.3892/etm.2017.4636
MLA
Ding, J., Niu, X., Su, Y., Li, X."Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury". Experimental and Therapeutic Medicine 14.2 (2017): 1609-1613.
Chicago
Ding, J., Niu, X., Su, Y., Li, X."Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1609-1613. https://doi.org/10.3892/etm.2017.4636