Open Access

Sivelestat sodium hydrate improves post‑traumatic knee osteoarthritis through nuclear factor‑κB in a rat model

  • Authors:
    • Xiaofeng Yu
    • Lijun Zhao
    • Zhiping Yu
    • Changzheng Yu
    • Jianfei Bi
    • Binglong Sun
    • Haibo Cong
  • View Affiliations

  • Published online on: June 27, 2017     https://doi.org/10.3892/etm.2017.4684
  • Pages: 1531-1537
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As a specific inhibitor of neutrophil elastase, sivelestat sodium hydrate has primarily been used in the treatment of acute lung injury caused by various factors since its approval in 2002. Sivelestat sodium hydrate also improves post‑traumatic knee osteoarthritis (KOA), although its underlying mechanisms of action have yet to be elucidated. The aim of the current study was to determine if sivelestat sodium hydrate improves post‑traumatic KOA through nuclear factor (NF)‑κB in a rat model. Treatment with sivelestat sodium hydrate significantly inhibited the induction of structural changes and significantly increased the vertical episode count and ipsilateral static weight bearing of the joint in KOA rats (all P<0.01). Sivelestat sodium hydrate significantly inhibited tumor necrosis factor‑α and interleukin‑6 production, serum nitrite levels, inducible nitric oxide synthase protein expression and high mobility group box 1 (HMGB1) secretion in KOA rats compared with the model group (all P<0.01). Sivelestat sodium hydrate also significantly suppressed p50/p65 DNA binding activity and NF‑κB and phosphorylated inhibitor of κB protein expression in the joints of KOA rats compared with the model group (all P<0.01). These results suggest that sivelestat sodium hydrate improves post‑traumatic KOA through HMGB1 and NF‑κB in rats.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yu X, Zhao L, Yu Z, Yu C, Bi J, Sun B and Cong H: Sivelestat sodium hydrate improves post‑traumatic knee osteoarthritis through nuclear factor‑κB in a rat model. Exp Ther Med 14: 1531-1537, 2017.
APA
Yu, X., Zhao, L., Yu, Z., Yu, C., Bi, J., Sun, B., & Cong, H. (2017). Sivelestat sodium hydrate improves post‑traumatic knee osteoarthritis through nuclear factor‑κB in a rat model. Experimental and Therapeutic Medicine, 14, 1531-1537. https://doi.org/10.3892/etm.2017.4684
MLA
Yu, X., Zhao, L., Yu, Z., Yu, C., Bi, J., Sun, B., Cong, H."Sivelestat sodium hydrate improves post‑traumatic knee osteoarthritis through nuclear factor‑κB in a rat model". Experimental and Therapeutic Medicine 14.2 (2017): 1531-1537.
Chicago
Yu, X., Zhao, L., Yu, Z., Yu, C., Bi, J., Sun, B., Cong, H."Sivelestat sodium hydrate improves post‑traumatic knee osteoarthritis through nuclear factor‑κB in a rat model". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1531-1537. https://doi.org/10.3892/etm.2017.4684