In‑hospital and long‑term outcomes of congestive heart failure: Predictive value of B‑type and amino‑terminal pro‑B‑type natriuretic peptides and their ratio

  • Authors:
    • Yuxiang Dai
    • Jun Yang
    • Atsutoshi Takagi
    • Hakuoh Konishi
    • Tetsuro Miyazaki
    • Hiroshi Masuda
    • Kazunori Shimada
    • Katsumi Miyauchi
    • Hiroyuki Daida
  • View Affiliations

  • Published online on: June 27, 2017     https://doi.org/10.3892/etm.2017.4686
  • Pages: 1715-1721
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Abstract

Relative changes in B‑type natriuretic peptide (BNP) and amino terminal pro‑BNP (NT‑proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these levels at the time of admission enable the prediction of outcomes with acute exacerbation remains unknown. The current study determined the abilities of BNP, NT‑proBNP and their ratio to predict in‑hospital and long‑term outcomes of patients with CHF. Patients who were admitted to the cardiac care unit of Juntendo University Hospital (Tokyo, Japan) with acute CHF onset were consecutively enrolled into the present observational study. Serum levels of BNP and NT‑proBNP were immediately measured on admission, and other biomarkers and clinical data were also investigated. Of 195 enrolled patients, 16 (8.2%) succumbed to CHF in hospital and 124 (69.3%) reached the endpoint of mortality or readmission following a median follow‑up of 14 months. Multiple linear regression analysis revealed body mass index, low density lipoprotein cholesterol, hemoglobin, estimated glomerular filtration rate and C‑reactive protein as independent predictors of the NT‑proBNP/BNP ratio. BNP, NT‑proBNP and their ratio were significantly higher among those who succumbed to CHF than in those who remained alive in hospital (P<0.05). Logistic regression analysis indicated that the ratio was an independent predictor for in‑hospital mortality and long‑term outcomes. In conclusion, the ratio of NT‑proBNP to BNP more effectively predicts in‑hospital outcomes than either factor alone and it may also help to predict outcomes among patients with acute exacerbation of HF.
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August-2017
Volume 14 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Dai Y, Yang J, Takagi A, Konishi H, Miyazaki T, Masuda H, Shimada K, Miyauchi K and Daida H: In‑hospital and long‑term outcomes of congestive heart failure: Predictive value of B‑type and amino‑terminal pro‑B‑type natriuretic peptides and their ratio. Exp Ther Med 14: 1715-1721, 2017.
APA
Dai, Y., Yang, J., Takagi, A., Konishi, H., Miyazaki, T., Masuda, H. ... Daida, H. (2017). In‑hospital and long‑term outcomes of congestive heart failure: Predictive value of B‑type and amino‑terminal pro‑B‑type natriuretic peptides and their ratio. Experimental and Therapeutic Medicine, 14, 1715-1721. https://doi.org/10.3892/etm.2017.4686
MLA
Dai, Y., Yang, J., Takagi, A., Konishi, H., Miyazaki, T., Masuda, H., Shimada, K., Miyauchi, K., Daida, H."In‑hospital and long‑term outcomes of congestive heart failure: Predictive value of B‑type and amino‑terminal pro‑B‑type natriuretic peptides and their ratio". Experimental and Therapeutic Medicine 14.2 (2017): 1715-1721.
Chicago
Dai, Y., Yang, J., Takagi, A., Konishi, H., Miyazaki, T., Masuda, H., Shimada, K., Miyauchi, K., Daida, H."In‑hospital and long‑term outcomes of congestive heart failure: Predictive value of B‑type and amino‑terminal pro‑B‑type natriuretic peptides and their ratio". Experimental and Therapeutic Medicine 14, no. 2 (2017): 1715-1721. https://doi.org/10.3892/etm.2017.4686