MicroRNA‑210 contributes to peripheral nerve regeneration through promoting the proliferation and migration of Schwann cells
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- Published online on: August 2, 2017 https://doi.org/10.3892/etm.2017.4869
- Pages: 2809-2816
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Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
Peripheral nerve injury impacts the daily life of affected individuals. MicroRNA (miR)‑210 is a multifunctional miR and has effects on the proliferation, migration and differentiation of cells. However, whether miR‑210 has effects on peripheral nerve regeneration has remained elusive. In the present study, the miR‑210 levels in a rat model of sciatic nerve injury were evaluated by reverse‑transcription quantitative PCR and the effects of miR‑210 on the proliferation and migration of Schwann cells were explored. Elevated miR‑210 levels were discovered in the sciatic nerve injury rat model. miR‑210 mimics were found to promote the proliferation and migration of Schwann cells, while miR‑210 inhibitor was found to inhibit the proliferation and migration of Schwann cells. Further study showed that miR‑210 had effects on the expression of growth‑associated protein‑43, myelin‑associated glycoprotein and myelin basic protein. These results showed that miR‑210 had effects on the proliferation and migration of Schwann cells and may be involved in the peripheral nerve regeneration.