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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October-2017 Volume 14 Issue 4

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway

  • Authors:
    • Qin Hu
    • Lina Gao
    • Bo Peng
    • Xinmin Liu

  • View Affiliations / Copyright

    Affiliations: College of Life Sciences and Bio‑Engineering, Beijing University of Technology, Beijing 100024, P.R. China, Institute of Chinese Materia Medica, Chinese Academy of Medical Sciences, Beijing 100700, P.R. China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3074-3080
    |
    Published online on: August 4, 2017
       https://doi.org/10.3892/etm.2017.4888
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Abstract

Baicalin and baicalein are flavonoid compounds derived from Scutellaria baicalensis Georgi. These compounds have been used in the treatment of numerous diseases, including fibrotic diseases. However, research regarding their antifibrotic effects and mechanism of action in renal fibrosis is limited. In the present study, normal rat kidney interstitial fibroblast (NRK‑49F) cells were stimulated with transforming growth factor (TGF)‑β1, with or without baicalin/baicalein, and assessed for proliferation, apoptosis, extracellular matrix (ECM) accumulation, collagen expression, TGF‑β1 expression and mothers against decapentaplegic homolog 3 (SMAD3) protein activation. The results revealed that baicalin and baicalein exhibited antifibrotic effects in vitro, whereas baicalein had a stronger inhibitory action compared with baicalin on TGF‑β1‑induced NRK‑49F cell proliferation, deposition of ECM, collagen synthesis, endogenous TGF‑β1 expression and phosphorylation of SMAD3. In conclusion, the findings of the present study indicate that baicalin and baicalein, particularly baicalein, exhibit antifibrotic effects in vitro by inhibiting the TGF‑β1 pathway. Therefore, these compounds have the potential to be developed as novel agents to treat renal fibrosis.

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Copy and paste a formatted citation
Spandidos Publications style
Hu Q, Gao L, Peng B and Liu X: Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway. Exp Ther Med 14: 3074-3080, 2017.
APA
Hu, Q., Gao, L., Peng, B., & Liu, X. (2017). Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway. Experimental and Therapeutic Medicine, 14, 3074-3080. https://doi.org/10.3892/etm.2017.4888
MLA
Hu, Q., Gao, L., Peng, B., Liu, X."Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway". Experimental and Therapeutic Medicine 14.4 (2017): 3074-3080.
Chicago
Hu, Q., Gao, L., Peng, B., Liu, X."Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3074-3080. https://doi.org/10.3892/etm.2017.4888
Copy and paste a formatted citation
x
Spandidos Publications style
Hu Q, Gao L, Peng B and Liu X: Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway. Exp Ther Med 14: 3074-3080, 2017.
APA
Hu, Q., Gao, L., Peng, B., & Liu, X. (2017). Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway. Experimental and Therapeutic Medicine, 14, 3074-3080. https://doi.org/10.3892/etm.2017.4888
MLA
Hu, Q., Gao, L., Peng, B., Liu, X."Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway". Experimental and Therapeutic Medicine 14.4 (2017): 3074-3080.
Chicago
Hu, Q., Gao, L., Peng, B., Liu, X."Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway". Experimental and Therapeutic Medicine 14, no. 4 (2017): 3074-3080. https://doi.org/10.3892/etm.2017.4888
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