Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase‑3, cyclooxygenase‑2 and inducible nitric oxide synthase expression

Zhu,Zhuanghui; Yi,Shuanglian; Shan,Zhonggui; Guo,Hongwei; Ke,Shaofan

doi:10.3892/etm.2017.5029

Effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin, caspase‑3, cyclooxygenase‑2 and inducible nitric oxide synthase expression

Authors:
- Zhuanghui Zhu
- Shuanglian Yi
- Zhonggui Shan
- Hongwei Guo
- Shaofan Ke
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Affiliations: Department of Cardiac Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China, Department of Gastroenterology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian 361003, P.R. China
Published online on: August 25, 2017 https://doi.org/10.3892/etm.2017.5029
Pages: 4377-4382

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Abstract

The aim of this study was to evaluate the effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function as assessed by cardiac troponin T (cTnT). A total of 60 patients were randomized into two groups: isoflurane + N2O inhalation (n=30) and propofol + fentanyl anesthesia (n=30). The findings demonstrated that there was no significant difference between the two experimental groups in terms of cTnT levels, demographic properties or hemodynamic parameters. Isoflurane + N2O inhalation and propofol + fentanyl anesthesia, respectively, were also investigated in a rat model of myocardial infarction. Myocardial cell damage, inflammation and oxidative stress levels, caspase‑3/9 activities and cyclooxygenase‑2 protein expression were markedly decreased, although there was no statistical significance difference between the two experimental groups. Notably, inducible nitric oxide synthase protein expression in the isoflurane + N2O inhalation group was significantly higher than that of the propofol + fentanyl anesthesia group (P<0.01). In conclusion, isoflurane + N2O inhalation and propofol + fentanyl anesthesia are not associated with risks for myocardial function.

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