Photodynamic therapy for biliary tract organ via a novel ultra‑small composite optical fiberscope

  • Authors:
    • Kazuhiko Kasuya
    • Kiyoshi Oka
    • Ryoko Soya
    • Takaaki Tsuchiya
    • Takao Itoi
    • Akihiko Tsuchida
  • View Affiliations

  • Published online on: August 28, 2017     https://doi.org/10.3892/etm.2017.5052
  • Pages: 4344-4348
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Photodynamic therapy (PDT) is a method used treat tumors via utilizing photodynamic reactions between photosensitive substances with tumor affinity and lasers. For overall bile duct cancers, PDT has been demonstrated to resolve stenosis and improve prognosis; however, when limited to intrahepatic bile duct cancers, modifications to the laser irradiation are necessary as surrounding hepatocytes incorporate a large amount of photosensitive substances. Furthermore, the intrahepatic bile duct is thin, and a guide sheath and thin fiber are necessary to transport laser irradiation probes to the target region. In the present study, a parallel‑type ultra‑small composite optical fiberscope (COF) with an outer diameter of 1 mm or smaller was developed to target a thin intrahepatic bile duct. PDT was performed using an animal model and talaporfin sodium (Laserphyrin), which is rapidly excreted by hepatocytes and is suitable for use with a long‑wavelength laser due to its high tissue penetrating ability. The results demonstrated that Laserphyrin does not cause necrotic changes in the normal biliary tract mucosa. In addition, COF images of sufficient quality were acquired. The present results suggest that COF may be used for the treatment of deep bile duct lesions.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kasuya K, Oka K, Soya R, Tsuchiya T, Itoi T and Tsuchida A: Photodynamic therapy for biliary tract organ via a novel ultra‑small composite optical fiberscope. Exp Ther Med 14: 4344-4348, 2017.
APA
Kasuya, K., Oka, K., Soya, R., Tsuchiya, T., Itoi, T., & Tsuchida, A. (2017). Photodynamic therapy for biliary tract organ via a novel ultra‑small composite optical fiberscope. Experimental and Therapeutic Medicine, 14, 4344-4348. https://doi.org/10.3892/etm.2017.5052
MLA
Kasuya, K., Oka, K., Soya, R., Tsuchiya, T., Itoi, T., Tsuchida, A."Photodynamic therapy for biliary tract organ via a novel ultra‑small composite optical fiberscope". Experimental and Therapeutic Medicine 14.5 (2017): 4344-4348.
Chicago
Kasuya, K., Oka, K., Soya, R., Tsuchiya, T., Itoi, T., Tsuchida, A."Photodynamic therapy for biliary tract organ via a novel ultra‑small composite optical fiberscope". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4344-4348. https://doi.org/10.3892/etm.2017.5052