Relationship of SOCS3 and TGF-β with IDO expression in early pregnancy chorionic villi and decidua

Liu,Wei; Huang,Yongli; Huang,Guanyou; Zhou,Congrong; Zeng,Xiaoling; Zhao,Shuyun; Wu,Lingfei; Zhou,Hua; Wu,Qingqing; Dai,Lujun

doi:10.3892/etm.2017.5142

Relationship of SOCS3 and TGF-β with IDO expression in early pregnancy chorionic villi and decidua

Authors:
- Wei Liu
- Yongli Huang
- Guanyou Huang
- Congrong Zhou
- Xiaoling Zeng
- Shuyun Zhao
- Lingfei Wu
- Hua Zhou
- Qingqing Wu
- Lujun Dai
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Affiliations: Reproductive Medicine Center, Department of Obstetrics and Gynecology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Gastroenterology, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, P.R. China, Central Laboratory, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Pathology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
Published online on: September 19, 2017 https://doi.org/10.3892/etm.2017.5142
Pages: 4817-4824
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

We aimed to investigate the expression of suppressors cytokine signaling (SOCS)-3, transforming growth factor (TGF)-β and indoleamine 2,3-dioxygense (IDO) and to analyse the relationship of SOCS3 and TGF-β with IDO expression in early pregnancy chorionic villi and decidua in the maternal-fetal interface. Western blot analysis and immunohistochemical method were used to detect the expression of TGF-β, SOCS3 and IDO in chorionic villi and decidua tissues of normal pregnant women. SOCS3, TGF-β and IDO protein was identified in chorionic villi and decidua tissues of normal pregnant women and there was a negative correlation between the expression of IDO and SOCS3, but TGF-β expression was positively correlated with IDO expression. The levels of IDO expression in the decidua from normal pregnancies were significantly higher than those in chorionic villi, while the expression of SOCS3 was no significant difference between decidua and chorionic villi. In normal physiological state of pregnancy, SOCS3 and TGF-β may be involved in the regulation of immune tolerance by positive or negative regulation of IDO expression at maternal fetal interface.

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