Anti‑aging effect of fullerenol on skin aging through derived stem cells in a mouse model

  • Authors:
    • Wei Li
    • Ning Li
    • Bing Sui
    • Daping Yang
  • View Affiliations

  • Published online on: September 21, 2017     https://doi.org/10.3892/etm.2017.5163
  • Pages: 5045-5050
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Abstract

Fullerenol is similar to graphite in terms of structure. In the present study, the anti‑aging effect of fullerenol on skin through derived stem cells in a mouse model was assessed and the potential mechanism of fullerenol was investigated. The anti‑aging effect of fullerenol effectively inhibited the retention rate of transplanted adipose‑derived stem cells and increased the thickness of the dermal portion of skin and collagen ratio in mice. The effect of fullerenol on the proliferation of stem cells was observed. Treatment with fullerenol effectively promoted the mRNA expression of Runt‑related transcription factor 2, alkaline phosphatase and osteocalcin in a mouse model of skin aging induced by D‑galactose. However, fullerenol treatment effectively suppressed the protein expression of peroxisome proliferator‑activated receptor‑γ (PPAR-γ) and increased forkhead box protein O1 (FoxO1) protein expression in the mice model of skin aging induced by D‑galactose. These results demonstrate that the anti‑aging effect of fullerenol on skin through derived stem cells may be mediated in mice via the PPAR-γ/FoxO1 signaling pathway.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li W, Li N, Sui B and Yang D: Anti‑aging effect of fullerenol on skin aging through derived stem cells in a mouse model. Exp Ther Med 14: 5045-5050, 2017.
APA
Li, W., Li, N., Sui, B., & Yang, D. (2017). Anti‑aging effect of fullerenol on skin aging through derived stem cells in a mouse model. Experimental and Therapeutic Medicine, 14, 5045-5050. https://doi.org/10.3892/etm.2017.5163
MLA
Li, W., Li, N., Sui, B., Yang, D."Anti‑aging effect of fullerenol on skin aging through derived stem cells in a mouse model". Experimental and Therapeutic Medicine 14.5 (2017): 5045-5050.
Chicago
Li, W., Li, N., Sui, B., Yang, D."Anti‑aging effect of fullerenol on skin aging through derived stem cells in a mouse model". Experimental and Therapeutic Medicine 14, no. 5 (2017): 5045-5050. https://doi.org/10.3892/etm.2017.5163