Open Access

Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins

  • Authors:
    • Wenwen Gao
    • Wangdi Wang
    • Wenjian Sun
    • Mingfang Wang
    • Na Zhang
    • Shuwen Yu
  • View Affiliations

  • Published online on: September 22, 2017     https://doi.org/10.3892/etm.2017.5191
  • Pages: 4627-4632
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the current study was to compare the antitumor efficiency of Phellinus igniarius polysaccharides (PIP) from six different origins and preliminarily investigate its potential mechanisms. PIP was extracted using the microwave extraction method. The corresponding in vivo antitumor efficacy was assessed in Kunming mice bearing H22 tumors and Gansu PIP (GPIP) was identified to have a significantly higher antitumor efficacy compared with the control group (P<0.05), while no significant difference was observed following treatment with PIP from different origins (P>0.05). The spleen index of the GPIP group significantly increased compared with the saline and CTX groups (P<0.01). The in vitro MTT assay of GPIP on HepG2 cells indicated that GPIP had no direct cytotoxicity. The serum immune cytokines of interleukin‑2, interleukin‑12 and interferon‑γ were assessed using the ELISA method. The concentration of all three serum cytokines significantly increased compared with saline and CTX groups (P<0.01) indicating that activating the immune system may be a potential antitumor mechanism. These results demonstrated that GPIP has great potential as a natural antitumor agent with immunomodulatory activity.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gao W, Wang W, Sun W, Wang M, Zhang N and Yu S: Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins. Exp Ther Med 14: 4627-4632, 2017.
APA
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., & Yu, S. (2017). Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins. Experimental and Therapeutic Medicine, 14, 4627-4632. https://doi.org/10.3892/etm.2017.5191
MLA
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., Yu, S."Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins". Experimental and Therapeutic Medicine 14.5 (2017): 4627-4632.
Chicago
Gao, W., Wang, W., Sun, W., Wang, M., Zhang, N., Yu, S."Antitumor and immunomodulating activities of six Phellinus igniarius polysaccharides of different origins". Experimental and Therapeutic Medicine 14, no. 5 (2017): 4627-4632. https://doi.org/10.3892/etm.2017.5191