Pathophysiological correlations between fundus fluorescein angiography and optical coherence tomography results in patients with idiopathic epiretinal membranes

Liu,Ju; Qian,Yong; Yang,Shunnan; Yan,Li; Wang,Yi; Gao,Meng; Liu,Limei; Xiao,Yuanyuan; Mo,Bin; Liu,Wu

doi:10.3892/etm.2017.5330

Pathophysiological correlations between fundus fluorescein angiography and optical coherence tomography results in patients with idiopathic epiretinal membranes

Authors:
- Ju Liu
- Yong Qian
- Shunnan Yang
- Li Yan
- Yi Wang
- Meng Gao
- Limei Liu
- Yuanyuan Xiao
- Bin Mo
- Wu Liu
View Affiliations

Affiliations: Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100073, P.R. China, Department of Ophthalmology, Beijing Electric Power Hospital, Capital Medical University, Beijing 100073, P.R. China, Vision Performance Institute, Pacific University College of Optometry, Forest Grove, OR 97116, USA
Published online on: October 18, 2017 https://doi.org/10.3892/etm.2017.5330
Pages: 5785-5792
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of the current study was to determine the association between fundus fluorescein angiography (FFA) image results, optical coherence tomography (OCT) imaging results and visual functions in patients with idiopathic epiretinal membranes (ERMs). A total of 80 eyes from 40 patients diagnosed with ERM were analyzed. Best‑corrected visual acuity (BCVA) and metamorphopsia were measured using the Early Treatment Diabetic Retinopathy Study eye chart and M‑charts, respectively. Macular thickness and volume were determined using OCT. Macular vascular leakage and distortion, and foveal avascular zone (FAZ) diameters were assessed using FFA. BCVA and M‑chart results confirmed macular degeneration in the affected eyes. The area of macular vascular leakage was positively correlated with macular volume (r=0.50; P=0.001). The ratio of FAZ diameters was negatively correlated with central macular thickness (r=‑0.41; P=0.008). The grade of macular vascular distortion was positively correlated with macular thickness (all r≥0.47; P<0.01) and volume (r=0.53; P<0.001). The results of the current study demonstrated that FFA may effectively identify the degree of changes in retinal macular vasculature. Vascular distortion, measured by FFA, may reflect changes in macular structure and visual functions. These results suggest a potential application of FFA in the pre‑ and post‑surgical evaluation of patients with ERMs.

View Figures

View References

1	Pearlstone AD: The incidence of idiopathic preretinal macular gliosis. Ann Ophthalmol. 17:378–380. 1985.PubMed/NCBI
2	Michels RG: A clinical and histopathologic study of epiretinal membranes affecting the macula and removed by vitreous surgery. Trans Am Ophthalmol Soc. 80:580–656. 1982.PubMed/NCBI
3	Schmitz-Valckenberg S, Holz FG, Bird AC and Spaide RF: Fundus autofluorescence imaging: Review and perspectives. Retina. 28:385–409. 2008. View Article : Google Scholar : PubMed/NCBI
4	Dell'omo R, Cifariello F, Dell'omo E, De Lena A, Di Iorio R, Filippelli M and Costagliola C: Influence of retinal vessel printings on metamorphopsia and retinal architectural abnormalities in eyes with idiopathic macular epiretinal membrane. Invest Ophthalmol Vis Sci. 54:7803–7811. 2013. View Article : Google Scholar : PubMed/NCBI
5	Niwa T, Terasaki H, Kondo M, Piao CH, Suzuki T and Miyake Y: Function and morphology of macula before and after removal of idiopathic epiretinal membrane. Invest Ophthalmol Vis Sci. 44:1652–1656. 2003. View Article : Google Scholar : PubMed/NCBI
6	Weinberger D, Stiebel-Kalish H, Priel E, Barash D, Axer-Siegel R and Yassur Y: Digital red-free photography for the evaluation of retinal blood vessel displacement in epiretinal membrane. Ophthalmology. 106:1380–1383. 1999. View Article : Google Scholar : PubMed/NCBI
7	Klein BR, Hiner CJ, Glaser BM, Murphy RP, Sjaarda RN and Thompson JT: Fundus photographic and fluorescein angiographic characteristics of pseudoholes of the macula in eyes with epiretinal membranes. Ophthalmology. 102:768–774. 1995. View Article : Google Scholar : PubMed/NCBI
8	Kadonosono K, Itoh N, Nomura E and Ohno S: Capillary blood flow velocity in patients with idiopathic epiretinal membranes. Retina. 19:536–539. 1999. View Article : Google Scholar : PubMed/NCBI
9	Maguire AM, Margherio RR and Dmuchowski C: Preoperative fluorescein angiographic features of surgically removed idiopathic epiretinal membranes. Retina. 14:411–416. 1994. View Article : Google Scholar : PubMed/NCBI
10	Bailey IL and Lovie-Kitchin JE: Vision acuity testing. From the laboratory to the clinic. Vision Res. 90:2–9. 2013. View Article : Google Scholar : PubMed/NCBI
11	Matsumoto C, Arimura E, Okuyama S, Takada S, Hashimoto S and Shimomura Y: Quantification of metamorphopsia in patients with epiretinal membranes. Invest Ophthalmol Vis Sci. 44:4012–4016. 2003. View Article : Google Scholar : PubMed/NCBI
12	Arimura E, Matsumoto C, Nomoto H, Hashimoto S, Takada S, Okuyama S and Shimomura Y: Correlations between M-CHARTS and PHP findings and subjective perception of metamorphopsia in patients with macular diseases. Invest Ophthalmol Vis Sci. 52:128–135. 2011. View Article : Google Scholar : PubMed/NCBI
13	Zhao F, Gandorfer A, Haritoglou C, Scheler R, Schaumberger MM, Kampik A and Schumann RG: Epiretinal cell proliferation in macular pucker and vitreomacular traction syndrome: Analysis of flat-mounted internal limiting membrane specimens. Retina. 33:77–88. 2013. View Article : Google Scholar : PubMed/NCBI
14	Wilkins JR, Puliafito CA, Hee MR, Duker JS, Reichel E, Coker JG, Schuman JS, Swanson EA and Fujimoto JG: Characterization of epiretinal membranes using optical coherence tomography. Ophthalmology. 103:2142–2151. 1996. View Article : Google Scholar : PubMed/NCBI
15	Massin P, Allouch C, Haouchine B, Metge F, Paques M, Tangui L, Erginay A and Gaudric A: Optical coherence tomography of idiopathic macular epiretinal membranes before and after surgery. Am J Ophthalmol. 130:732–739. 2000. View Article : Google Scholar : PubMed/NCBI
16	Arichika S, Hangai M and Yoshimura N: Correlation between thickening of the inner and outer retina and visual acuity in patients with epiretinal membrane. Retina. 30:503–508. 2010. View Article : Google Scholar : PubMed/NCBI
17	Michalewski J, Michalewska Z, Cisiecki S and Nawrocki J: Morphologically functional correlations of macular pathology connected with epiretinal membrane formation in spectral optical coherence tomography (SOCT). Graefes Arch Clin Exp Ophthalmol. 245:1623–1631. 2007. View Article : Google Scholar : PubMed/NCBI
18	Theodossiadis PG, Grigoropoulos VG, Kyriaki T, Emfietzoglou J, Vergados J, Nikolaidis P and Theodossiadis GP: Evolution of idiopathic epiretinal membrane studied by optical coherence tomography. Eur J Ophthalmol. 18:980–988. 2008.PubMed/NCBI
19	Pilli S, Lim P, Zawadzki RJ, Choi SS, Werner JS and Park SS: Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane: Correlation between macular morphology and visual function. Eye (Lond). 25:775–783. 2011. View Article : Google Scholar : PubMed/NCBI
20	Gass JDM: Stereoscopic Atlas Of Macular Diseases: Diagnosis And Treatment. 3rd edition. CV Mosby, St. Louis, MO: 1997
21	Falkner-Radler CI, Glittenberg C, Hagen S, Benesch T and Binder S: Spectral-domain optical coherence tomography for monitoring epiretinal membrane surgery. Ophthalmology. 117:798–805. 2010. View Article : Google Scholar : PubMed/NCBI
22	Inoue M, Morita S, Watanabe Y, Kaneko T, Yamane S, Kobayashi S, Arakawa A and Kadonosono K: Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane. Am J Ophthalmol. 150:834–839. 2010. View Article : Google Scholar : PubMed/NCBI
23	Shiono A, Kogo J, Klose G, Takeda H, Ueno H, Tokuda N, Inoue J, Matsuzawa A, Kayama N, Ueno S and Takagi H: Photoreceptor outer segment length: A prognostic factor for idiopathic epiretinal membrane surgery. Ophthalmology. 120:788–794. 2013. View Article : Google Scholar : PubMed/NCBI
24	Arimura E, Matsumoto C, Okuyama S, Takada S, Hashimoto S and Shimomura Y: Retinal contraction and metamorphopsia scores in eyes with idiopathic epiretinal membrane. Invest Ophthalmol Vis Sci. 46:2961–2966. 2005. View Article : Google Scholar : PubMed/NCBI
25	Okamoto F, Sugiura Y, Okamoto Y, Hiraoka T and Oshika T: Associations between metamorphopsia and foveal microstructure in patients with epiretinal membrane. Invest Ophthalmol Vis Sci. 53:6770–6775. 2012. View Article : Google Scholar : PubMed/NCBI
26	Watanabe A, Arimoto S and Nishi O: Correlation between metamorphopsia and epiretinal membrane optical coherence tomography findings. Ophthalmology. 116:1788–1793. 2009. View Article : Google Scholar : PubMed/NCBI