Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

Song,Yali; Liu,Jing; Qiu,Zhuolin; Chen,Donghong; Luo,Chen; Liu,Xiaoning; Hua,Rui; Zhu,Xi; Lin,Yanling; Li,Lina; Liu,Wenlian; Quan,Song

doi:10.3892/etm.2017.5390

Advanced oxidation protein products from the follicular microenvironment and their role in infertile women with endometriosis

Authors:
- Yali Song
- Jing Liu
- Zhuolin Qiu
- Donghong Chen
- Chen Luo
- Xiaoning Liu
- Rui Hua
- Xi Zhu
- Yanling Lin
- Lina Li
- Wenlian Liu
- Song Quan
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Affiliations: Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Hengsheng Hospital, Southern Medical University, Shenzhen, Guangdong 510888, P.R. China, Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
Published online on: October 30, 2017 https://doi.org/10.3892/etm.2017.5390
Pages: 479-486

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Abstract

Endometriosis (EM) is associated with oxidative stress. Advanced oxidation protein products (AOPPs) are novel markers of oxidative stress, which serve an important role as an inflammatory mediator in various chronic diseases. In order to examine the role of AOPPs in infertile women with EM, the present study analyzed the levels of AOPPs, estradiol (E2) and progesterone (P4) in the follicular fluid (FF) of 89 women with or without EM undergoing in vitro fertilization (IVF). The AOPP concentration in the FF of the EM group was significantly higher when compared with that of the control group (51.5±22.4 vs. 41.8±18.3 µmol/l; P<0.05). However, the FF P4 levels and blastocyst rate were significantly lower in the EM group compared with the control group (P4:1,249.6±465.4 vs. 1,752.7±565.4 ng/ml, P<0.05; blastocyst rate: 0.511±0.322 vs. 0.662±0.278; P<0.05). The AOPP concentration and P4 level in the FF presented a significant negative correlation in the EM and control groups, as well as in the total cohort of patients (EM group: r=‑0.406, P=0.006; control group: r=‑0.315, P=0.035; total: r=‑0.421, P<0.001). In addition, there was a significant negative correlation between the FF AOPP concentrations and blastocyst rate in the EM group and in the total cohort (EM group: r=‑0.376, P=0.012; total: r=‑0.367, P<0.001). In conclusion, these results suggested that AOPPs may be a potentially effective marker for predicting the oocyte quality and outcomes of IVF in infertile women with EM.

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