Open Access

A model of anterior cruciate ligament injury in cynomolgus monkeys developed via arthroscopic surgery

  • Authors:
    • Lei Zhang
    • Taiyuan Guan
    • Ji Qi
    • Shaoqun Zhang
    • Xin Zhou
    • Yang Liu
    • Shijie Fu
  • View Affiliations

  • Published online on: January 8, 2018     https://doi.org/10.3892/etm.2018.5722
  • Pages: 2239-2246
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The anterior cruciate ligament (ACL) is an important structure that maintains the stability of knee joints. Animal models of ACL injury are helpful to explore its underlying mechanisms, and strategies for prevention, treatment and rehabilitation. Therefore, the aim of the present study was to develop an efficient model of ACL injury in cynomolgus monkeys via arthroscopic techniques. In the present study, 18 cynomolgus monkeys were randomly divided into a model group (n=6), a sham operation group (n=6) and a blank control group (n=6). One‑quarter of the ACL was removed under arthroscopy in the model group. In the sham operation group, only arthroscopic exploration was performed as a control. In the blank control group, monkeys were housed under the same conditions for the same length of time. Magnetic resonance imaging examination was performed pre‑ and post‑operatively, as well as measurements of the circumference of the thigh and calf, and of the maximum flexion degree of the knee. Anterior drawer test, Lachman test and pivot‑shift tests were also performed. The results revealed that the injured side of the knees in the model group became unstable, as determined from evaluation of the physical tests. In conclusion, based on these findings, the modeling method of ACL injury was effective, and may contribute to the associated research concerning ACL injury.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang L, Guan T, Qi J, Zhang S, Zhou X, Liu Y and Fu S: A model of anterior cruciate ligament injury in cynomolgus monkeys developed via arthroscopic surgery. Exp Ther Med 15: 2239-2246, 2018.
APA
Zhang, L., Guan, T., Qi, J., Zhang, S., Zhou, X., Liu, Y., & Fu, S. (2018). A model of anterior cruciate ligament injury in cynomolgus monkeys developed via arthroscopic surgery. Experimental and Therapeutic Medicine, 15, 2239-2246. https://doi.org/10.3892/etm.2018.5722
MLA
Zhang, L., Guan, T., Qi, J., Zhang, S., Zhou, X., Liu, Y., Fu, S."A model of anterior cruciate ligament injury in cynomolgus monkeys developed via arthroscopic surgery". Experimental and Therapeutic Medicine 15.3 (2018): 2239-2246.
Chicago
Zhang, L., Guan, T., Qi, J., Zhang, S., Zhou, X., Liu, Y., Fu, S."A model of anterior cruciate ligament injury in cynomolgus monkeys developed via arthroscopic surgery". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2239-2246. https://doi.org/10.3892/etm.2018.5722