Anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device: Manufacture and use in intervertebral disc repair

Bao,Da; Li,Dawei

doi:10.3892/etm.2018.5745

Anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device: Manufacture and use in intervertebral disc repair

Authors:
- Da Bao
- Dawei Li
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Affiliations: Department of Orthopedics, The 309th Hospital of PLA, Beijing 100091, P.R. China
Published online on: January 12, 2018 https://doi.org/10.3892/etm.2018.5745
Pages: 3040-3044

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Abstract

Artificial disc replacement alone is unable to completely cure cervical degenerative diseases; thus, a stabilization device markedly improves patient recovery. In order to meet this requirement, an anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device (ASI combining PDN/FD) was developed. An artificial disc was designed and manufactured using polyvinyl alcohol hydrogel (PVA‑H) with a repeated freeze‑melting technique, and subsequently the dehydration and swelling properties of the PVA‑H were investigated. A canine animal model was then used to compare the differences in the degeneration of cervical discs adjacent to the operative segment with PDN/FD against a plate fixation system, without the interferences of brace intensity, which was ensured by pressure monitoring the dog's intervertebral disc adjacent to operative segments. The in vivo results demonstrated a clear decrease in the degeneration of the adjacent disc with the use of PDN/FD as compared with the plate fixation system. In conclusion, PDN/FD may offer a promising method for the treatment of cervical degenerative disease.

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