Open Access

miR-372 promotes breast cancer cell proliferation by directly targeting LATS2

  • Authors:
    • Xueyuan Cheng
    • Junqiang Chen
    • Zhong Huang
  • View Affiliations

  • Published online on: January 17, 2018     https://doi.org/10.3892/etm.2018.5761
  • Pages: 2812-2817
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRs) have previously been demonstrated to be important in the tumorigenesis and progression of breast cancer. miR‑372 was previously revealed to be involved in various types of human cancer, however its function in breast cancer remains largely unknown. The present study demonstrated that miR‑372 is frequently overexpressed in breast cancer cell lines and tissues. The downregulation of miR‑372 markedly inhibited cell proliferation, arrested the cell cycle in the G1/S phase, and increased the apoptosis of breast cancer cells. Consistently, an in vivo xenograft study also demonstrated the suppressive effects of miR‑372 knockdown on tumor growth. Further studies revealed that miR‑372 modulated the expression of large tumor suppressor kinase 2 (LATS2) by directly targeting its 3'‑untranslated region in breast cancer cells. Furthermore, silencing of LATS2 was able to rescue the effect of the miR‑372 inhibitor. Overall, the results suggest that miR‑372 functions as an oncogenic miRNA in breast cancer by targeting LATS2.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cheng X, Chen J and Huang Z: miR-372 promotes breast cancer cell proliferation by directly targeting LATS2. Exp Ther Med 15: 2812-2817, 2018
APA
Cheng, X., Chen, J., & Huang, Z. (2018). miR-372 promotes breast cancer cell proliferation by directly targeting LATS2. Experimental and Therapeutic Medicine, 15, 2812-2817. https://doi.org/10.3892/etm.2018.5761
MLA
Cheng, X., Chen, J., Huang, Z."miR-372 promotes breast cancer cell proliferation by directly targeting LATS2". Experimental and Therapeutic Medicine 15.3 (2018): 2812-2817.
Chicago
Cheng, X., Chen, J., Huang, Z."miR-372 promotes breast cancer cell proliferation by directly targeting LATS2". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2812-2817. https://doi.org/10.3892/etm.2018.5761