Open Access

Effects of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis

  • Authors:
    • Yanshuang Li
    • Weijia Sun
  • View Affiliations

  • Published online on: January 18, 2018     https://doi.org/10.3892/etm.2018.5768
  • Pages: 2879-2883
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The purpose of this study was to determine the effect of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis (TB). We selected 32 patients with AIDS combined with TB infection in our hospital and 30 healthy individual as controls. The Th17/Treg ratio in peripheral blood lymphocytes was detected by flow cytometry. Compared with healthy subjects, Th17 cells first declined in HIV patients with TB, but gradually increased over the course of the disease. Treg showed an increasing trend in HIV patients with TB. The Th17/Treg ratio was significantly altered as the condition gradually deteriorated. ELISA showed that interleukin (IL)-17, IL-6 and IL-10 in patients with HIV complicated with TB were significantly lower than in healthy subjects. The imbalance of Th17/Treg cells can promote HIV virus replication in AIDS patients with TB infection, which can aggravate the condition.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li Y and Sun W: Effects of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis. Exp Ther Med 15: 2879-2883, 2018.
APA
Li, Y., & Sun, W. (2018). Effects of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis. Experimental and Therapeutic Medicine, 15, 2879-2883. https://doi.org/10.3892/etm.2018.5768
MLA
Li, Y., Sun, W."Effects of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis". Experimental and Therapeutic Medicine 15.3 (2018): 2879-2883.
Chicago
Li, Y., Sun, W."Effects of Th17/Treg cell imbalance on HIV replication in patients with AIDS complicated with tuberculosis". Experimental and Therapeutic Medicine 15, no. 3 (2018): 2879-2883. https://doi.org/10.3892/etm.2018.5768