Discrimination of malignant transformation from benign endometriosis using a near‑infrared approach

  • Authors:
    • Naoki Kawahara
    • Yuki Yamada
    • Fuminori Ito
    • Wataru Hojo
    • Takuya Iwabuchi
    • Hiroshi Kobayashi
  • View Affiliations

  • Published online on: January 19, 2018     https://doi.org/10.3892/etm.2018.5779
  • Pages: 3000-3005
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Abstract

The aim of the present single-center retrospective study was to investigate the discrimination of malignant transformation from ovarian endometrioma (OE) using a near‑infrared approach ex vivo. Cystic fluid samples were collected from patients with OE (n=34) and endometriosis‑associated ovarian cancer (EAOC) (n=12). The light reflected from each sample of cystic fluid [change in luminance, Δl (cd/m2) = background luminance‑cystic fluid luminance at 800 nm] was spectrally measured by a near‑infrared CCD camera with band‑path filter (800 nm). The Δl in EAOC was significantly lower compared with that in OE. On regression analysis, a positive correlation was observed between the Δl and Hb level in the cystic fluid, and this association was exponential. The diagnostic sensitivity and specificity of Δl was 83.3 and 94.1% at the cutoff value of 21.5 cd/m2, with an area under the ROC curve of 0.897. The present ex vivo study potentially provides a powerful near‑infrared approach for quantitative discrimination between EAOC and benign OE, with high sensitivity and specificity, which may have clinical applications.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Kawahara N, Yamada Y, Ito F, Hojo W, Iwabuchi T and Kobayashi H: Discrimination of malignant transformation from benign endometriosis using a near‑infrared approach. Exp Ther Med 15: 3000-3005, 2018
APA
Kawahara, N., Yamada, Y., Ito, F., Hojo, W., Iwabuchi, T., & Kobayashi, H. (2018). Discrimination of malignant transformation from benign endometriosis using a near‑infrared approach. Experimental and Therapeutic Medicine, 15, 3000-3005. https://doi.org/10.3892/etm.2018.5779
MLA
Kawahara, N., Yamada, Y., Ito, F., Hojo, W., Iwabuchi, T., Kobayashi, H."Discrimination of malignant transformation from benign endometriosis using a near‑infrared approach". Experimental and Therapeutic Medicine 15.3 (2018): 3000-3005.
Chicago
Kawahara, N., Yamada, Y., Ito, F., Hojo, W., Iwabuchi, T., Kobayashi, H."Discrimination of malignant transformation from benign endometriosis using a near‑infrared approach". Experimental and Therapeutic Medicine 15, no. 3 (2018): 3000-3005. https://doi.org/10.3892/etm.2018.5779