Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters

Baltzis,Dimitrios; Meimeti,Evangelia; Grammatikopoulou,Maria  G.; Roustit,Matthieu; Mavrogonatou,Eleni; Kletsas,Dimitris; Efraimidou,Smaragda; Manes,Christos; Nikolouzakis,Taxiarchis   K.; Tsiaoussis,John; Tsatsakis,Aristides   M.; Spandidos,Demetrios   A.; Trakatelli,Christina-Maria; Drakoulis,Nikolaos

doi:10.3892/etm.2018.5798

Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters

Authors:
- Dimitrios Baltzis
- Evangelia Meimeti
- Maria G. Grammatikopoulou
- Matthieu Roustit
- Eleni Mavrogonatou
- Dimitris Kletsas
- Smaragda Efraimidou
- Christos Manes
- Taxiarchis K. Nikolouzakis
- John Tsiaoussis
- Aristides M. Tsatsakis
- Demetrios A. Spandidos
- Christina-Maria Trakatelli
- Nikolaos Drakoulis
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Affiliations: Diabetes Center, Papageorgiou General Hospital, 56403 Thessaloniki, Greece, Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece, Department of Nutrition and Dietetics, Alexander Technological Educational Institute, 57400 Thessaloniki, Greece, HP2 Laboratory, University of Grenoble Alpes, 38700 La Tronche Université Grenoble Alpes, France, Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and Applications, National Centre for Scientific Research ‘Demokritos’, 15341 Athens, Greece, Department of Hematology, Papageorgiou General Hospital, 56403 Thessaloniki, Greece, Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Greece, Department of Forensic Sciences and Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece, Third Department of Internal Medicine, Papageorgiou General Hospital, 56403 Thessaloniki, Greece
Published online on: January 25, 2018 https://doi.org/10.3892/etm.2018.5798
Pages: 3420-3424
Copyright: © Baltzis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mellitus (T2DM) were studied. Patients were allocated into two groups according to the absence or presence of active foot ulcers as follows: Νon-ulcer group (N=58) and ulcer group (N=32). Our data revealed that the patients with diabetic ulcers had significantly greater waist circumference and neuropathy disability score, while exhibiting lower telomerase activity, indicating the possible existence of a common clinical profile among ulcer-bearing diabetic patients. Validation of our findings by extending the study in larger patient groups may contribute to the understanding of T2DM pathophysiology and its main clinical implications.

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