Pterostilbene attenuates acute kidney injury in septic mice

Xia,Yizi; Chen,Ying; Tang,Luming; Wang,Zheng; Zheng,Yu

doi:10.3892/etm.2018.5808

Pterostilbene attenuates acute kidney injury in septic mice

Authors:
- Yizi Xia
- Ying Chen
- Luming Tang
- Zheng Wang
- Yu Zheng
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Affiliations: Department of Emergency, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, Department of Nephrology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China
Published online on: January 30, 2018 https://doi.org/10.3892/etm.2018.5808
Pages: 3551-3555

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Abstract

Acute kidney injury (AKI) is a severe complication of sepsis with a high mortality and morbidity. Pterostilbene (Pte) has been suggested to confer anti‑apoptotic and anti‑inflammatory effects. In the current study, the effects of Pte on AKI were evaluated in septic mice. Cecal ligation and puncture surgery was performed to induce sepsis. The results suggested that Pte administration significantly decreased the levels of serum urea nitrogen and creatinine, and improved the survival rate of septic mice. Additionally, the renal injury induced by sepsis was attenuated by pterostilbene treatment. Notably, pterostilbene reduced Bcl‑2‑associated X protein expression, and levels of interleukin‑1β and tumor necrosis factor‑α, and upregulated B‑cell lymphoma 2 expression. The results indicate that pterostilbene may serve as a potential therapeutic candidate for the treatment of AKI induced by sepsis.

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