Open Access

Evaluation of effect of atorvastatin on left ventricular systolic function in rats with myocardial infarction via 2D-STI technique

  • Authors:
    • Yan Hua
    • Manying Xie
    • Jiabao Yin
    • Yu Wang
    • Ling Gan
    • Ming Sang
    • Xiaodong Sun
    • Mingyang Li
    • Shanjun Liu
    • Jinzhi Xu
  • View Affiliations

  • Published online on: March 13, 2018     https://doi.org/10.3892/etm.2018.5951
  • Pages: 4386-4394
  • Copyright: © Hua et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This report aims to evaluate the effect of atorvastatin (Ator) on left ventricular systolic function in myocardial infarction (MI) rats. Forty healthy adult Sprague-Dawley rats were randomly divided into four groups: Ator group, MI group, sham-operation group and normal group. The left anterior descending coronary arteries were ligated to establish the MI model; after modeling, the Ator group was treated with Ator for 4 consecutive weeks. The echocardiographic detection was performed; the left ventricular myocardial systolic peak velocities, strain and strain rates were analyzed using the 2D-STI technique. After 4 weeks, myocardial tissues were taken from all rats and received the pathological examination. Left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) in Ator group and MI group were increased after operation, but left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were decreased; myocardial function were decreased significantly (p<0.05). After Ator treatment, myocardial function at the 3rd and 4th week after operation increased significantly (p<0.05). After Ator treatment, LVEDD and LVESD decreased while LVEF and LVFS increased in Ator group at the 3rd and 4th week after operation compared with MI group (p<0.05). At the 4th week after operation, LVEDD and LVESD in Ator group were decreased compared with those at the 1st and 2nd week after operation, but LVEF and LVFS were increased compared with those at the 1st , 2nd and 3rd week after operation (p<0.05). Pathological examination showed that necrosis and fibrosis of myocardial cells and inflammatory reaction were obvious in MI group. The inflammatory reaction of myocardial cells and myocardial fibrosis were lighter in Ator group. Ator can effectively improve the left ventricular systolic function in MI rats, which could be related to the reduction of response to inflammation and fibrosis.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Hua Y, Xie M, Yin J, Wang Y, Gan L, Sang M, Sun X, Li M, Liu S, Xu J, Xu J, et al: Evaluation of effect of atorvastatin on left ventricular systolic function in rats with myocardial infarction via 2D-STI technique. Exp Ther Med 15: 4386-4394, 2018
APA
Hua, Y., Xie, M., Yin, J., Wang, Y., Gan, L., Sang, M. ... Xu, J. (2018). Evaluation of effect of atorvastatin on left ventricular systolic function in rats with myocardial infarction via 2D-STI technique. Experimental and Therapeutic Medicine, 15, 4386-4394. https://doi.org/10.3892/etm.2018.5951
MLA
Hua, Y., Xie, M., Yin, J., Wang, Y., Gan, L., Sang, M., Sun, X., Li, M., Liu, S., Xu, J."Evaluation of effect of atorvastatin on left ventricular systolic function in rats with myocardial infarction via 2D-STI technique". Experimental and Therapeutic Medicine 15.5 (2018): 4386-4394.
Chicago
Hua, Y., Xie, M., Yin, J., Wang, Y., Gan, L., Sang, M., Sun, X., Li, M., Liu, S., Xu, J."Evaluation of effect of atorvastatin on left ventricular systolic function in rats with myocardial infarction via 2D-STI technique". Experimental and Therapeutic Medicine 15, no. 5 (2018): 4386-4394. https://doi.org/10.3892/etm.2018.5951