Potential mechanism and drug candidates for sepsis‑induced acute lung injury

Xu,Chenyuan; Guo,Zhengqiang; Zhao,Chuncheng; Zhang,Xufeng; Wang,Zheng

doi:10.3892/etm.2018.6001

Potential mechanism and drug candidates for sepsis‑induced acute lung injury

Authors:
- Chenyuan Xu
- Zhengqiang Guo
- Chuncheng Zhao
- Xufeng Zhang
- Zheng Wang
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Affiliations: Department of Thoracic Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China
Published online on: March 28, 2018 https://doi.org/10.3892/etm.2018.6001
Pages: 4689-4696
Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to explore the mechanisms underlying sepsis‑induced acute lung injury (ALI) and identify more effective therapeutic strategies to treat it. The gene expression data set GSE10474 was downloaded and assessed to identify differentially expressed genes (DEGs). Principal component analysis, functional enrichment analysis and differential co‑expression analysis of DEGs were performed. Furthermore, potential target drugs for key DEGs were assessed. A total of 209 DEGs, including 107 upregulated and 102 downregulated genes were screened. A number of DEGs, including zinc finger and BTB domain containing 17 (ZBTB17), heat shock protein 90 kDa β, member 1 (HSP90B1) and major histocompatibility complex, class II, DR α were identified. Furthermore, gene ontology terms including antigen processing and presentation, glycerophospholipid metabolism, transcriptional misregulation in cancer, thyroid hormone synthesis and pathways associated with diseases, such as asthma were identified. In addition, a differential co‑expression network containing ubiquitin‑conjugating enzyme E2 D4, putative and tubulin, γ complex associated protein 3 was constructed. Furthermore, a number of gene‑drug interactions, including between HSP90B1 and adenosine‑5'‑diphosphate and radicicol, were identified. Therefore, DEGs, including ZBTB17 and HSP90B1, may be important in the pathogenesis of sepsis‑induced ALI. Furthermore, drugs including adenosine‑5'‑diphosphate may be novel drug candidates to treat patients with ALI.

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