Open Access

Effect of hyperbaric oxygen combined with nimodipine on treatment of diffuse brain injury

  • Authors:
    • Jianping Sun
    • Jun Zheng
    • Feng Wang
    • Gengshen Zhang
    • Jianliang Wu
  • View Affiliations

  • Published online on: April 10, 2018     https://doi.org/10.3892/etm.2018.6045
  • Pages: 4651-4658
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to was investigate the treatment efficacy of hyperbaric oxygen (HBO) combined with nimodipine on diffuse brain injury. AA total of 80 patients with diffuse brain injury were randomly divided into four groups: Group A, conventional treatment; Group B, conventional treatment + nimodipine; Group C, conventional treatment + HBO therapy and Group D, conventional treatment + nimodipine + HBO therapy. The Glasgow Coma Scale (GCS) score and serum tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β levels were assessed before treatment and at 8, 24, 48 and 72 h after treatment. The bilateral middle cerebral arterial blood flow velocity (VmMCA) was measured by transcranial Doppler ultrasound. The results indicated that serum TNF‑α and IL‑1β were significantly decreased in all groups at 24, 48 and 72 h after treatment, compared with 8 h after treatment (P<0.05), with Group D exhibiting the largest decrease. The serum TNF‑α, IL‑1β and VmMCA peaked at 8 h and gradually decreased over the treatment period. VmMCA was decreased in Group B and D compared with Group A and C, and the decrease rate was higher in Group D compared with Group B (P<0.05). GCS scores were significantly increased in all groups at 24, 48 and 72 h after treatment compared with 8 h after treatment (P<0.05), with Group D exhibiting the largest increase. Serum TNF‑α and IL‑1β levels were positively correlated with VmMCA (P<0.05) and negatively correlated with GCS (P<0.05). Punctate hemorrhage was observed in all groups on CT before treatment, with a value of 66±3 HU. Punctate hemorrhage was observed to decrease over time in CT images, and CT values were significantly decreased in all groups at 8, 24, 48 and 72 h compared with before treatment (P<0.05). CT values were significantly lower in group D compared with groups A, B and C (P<0.05) at all time points. Serum TNF‑α and IL‑1β levels were positively correlated with CT value (P<0.05). In conclusion, HBO combined with nimodipine exhibited increased efficacy in the treatment of brain injury compared with either treatment alone.
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June-2018
Volume 15 Issue 6

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Copy and paste a formatted citation
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Spandidos Publications style
Sun J, Zheng J, Wang F, Zhang G and Wu J: Effect of hyperbaric oxygen combined with nimodipine on treatment of diffuse brain injury. Exp Ther Med 15: 4651-4658, 2018
APA
Sun, J., Zheng, J., Wang, F., Zhang, G., & Wu, J. (2018). Effect of hyperbaric oxygen combined with nimodipine on treatment of diffuse brain injury. Experimental and Therapeutic Medicine, 15, 4651-4658. https://doi.org/10.3892/etm.2018.6045
MLA
Sun, J., Zheng, J., Wang, F., Zhang, G., Wu, J."Effect of hyperbaric oxygen combined with nimodipine on treatment of diffuse brain injury". Experimental and Therapeutic Medicine 15.6 (2018): 4651-4658.
Chicago
Sun, J., Zheng, J., Wang, F., Zhang, G., Wu, J."Effect of hyperbaric oxygen combined with nimodipine on treatment of diffuse brain injury". Experimental and Therapeutic Medicine 15, no. 6 (2018): 4651-4658. https://doi.org/10.3892/etm.2018.6045