[18F]Fluorodeoxyglucose positron emission tomography/computed tomography for diagnosing polymyositis/dermatomyositis

Sun,Lu; Dong,Yuanfei; Zhang,Na; Lv,Xing; Chen,Qiusong; Wei,Wei

doi:10.3892/etm.2018.6066

[18F]Fluorodeoxyglucose positron emission tomography/computed tomography for diagnosing polymyositis/dermatomyositis

Authors:
- Lu Sun
- Yuanfei Dong
- Na Zhang
- Xing Lv
- Qiusong Chen
- Wei Wei
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Affiliations: Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of PET‑CT Diagnostics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
Published online on: April 13, 2018 https://doi.org/10.3892/etm.2018.6066
Pages: 5023-5028

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Abstract

[18F]fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG‑PET/CT) is useful for diagnosing cancers and inflammatory diseases. A polymyositis/dermatomyositis (PM/DM) lesion is an inflammatory heterogeneous disease of the striated muscle. In the present study, the maximum standardized uptake value (SUVmax) was compared between 22 cases with definite or probable PM/DM (PM/DM group) that underwent [18F]FDG‑PET/CT examination and the same number of patients with no myopathy. The average proximal muscle FDG uptake value (SUVaverage) for each patient was represented by calculating the average of the SUVmax for these muscles bilaterally. The correlation between creatine kinase (CK), serum creatine kinase isoenzyme, myodynamia of the proximal limb girdle muscle and SUVmax of each muscle group were analyzed. The results indicated that the SUVmax was markedly different between the PM/DM group and the non‑myopathy group. It was demonstrated that [18F]FDG‑PET/CT has a diagnostic value for PM/DM. The serum CK levels and the SUVaverage were negatively correlated with myodynamia. [18F]FDG‑PET/CT may be used for examination to assess the severity of myositis. Furthermore, it may provide detection sites for muscle biopsy in patients with myositis.

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