Diagnostic value of detection of serum β‑HCG and CT‑IgG combined with transvaginal ultrasonography in early tubal pregnancy

Xin,Hongyan; Liu,Wenlian; Li,Ping

doi:10.3892/etm.2018.6166

Diagnostic value of detection of serum β‑HCG and CT‑IgG combined with transvaginal ultrasonography in early tubal pregnancy

Authors:
- Hongyan Xin
- Wenlian Liu
- Ping Li
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Affiliations: Department of Ultrasonography, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China, Department of Obstetrics and Gynecology, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China
Published online on: May 14, 2018 https://doi.org/10.3892/etm.2018.6166
Pages: 277-281

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Abstract

The diagnostic value of detection of serum β‑human chorionic gonadotropin (β‑HCG) and Chlamydia trachomatis immunoglobulin G (CT‑IgG) combined with transvaginal ultrasonography in early tubal pregnancy was investigated. A total of 55 patients with early tubal pregnancy were selected as the tubal pregnancy group, while 55 subjects of normal intrauterine pregnancy were enrolled as the intrauterine pregnancy group. Transvaginal ultrasonography and quantitative detection of serum β‑HCG and CT‑IgG were performed for all patients, and the clinical examination results were analyzed and compared. The endometrial thickness and serum β‑HCG level of patients with early tubal pregnancy were significantly lower than those of women with intrauterine pregnancy (6.7±1.5 vs. 11.6±1.2 mm; 776±109 vs. 5,598±187 U/l), and the differences were statistically significant (p<0.01); the serum CT‑IgG antibody positive rate of patients in tubal pregnancy group (49.1%) was significantly higher than that in intrauterine pregnancy group (12.7%) (p<0.01); the serum CT‑IgG antibody positive rates of patients with degree I, Ⅱ and Ⅲ of pelvic adhesion intubal pregnancy group were 28.6, 75.0 and 81.8%, respectively; the more severe the pelvic adhesion was, the higher the CT‑IgG positive rate would be. The diagnostic coincidence rate of combined detection was significantly higher than that of single detection of serum β‑HCG, progesterone and endometrial thickness. The detection of serum β‑HCG and CT‑IgG combined with transvaginal ultrasonography can diagnose the early tubal pregnancy soonest possible, and help choose the appropriate therapeutic methods depending on the situation to reduce the tubal damage of patients, so as to provide a reliable basis for the diagnosis, treatment and prognosis, and it has important clinical application value.

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1	Stulberg DB, Cain LR, Dahlquist I and Lauderdale DS: Ectopic pregnancy rates in the Medicaid population. Am J Obstet Gynecol. 208:274.e1–274.e7. 2013. View Article : Google Scholar
2	Ma LK, Cao DY, Yang JX, Liu JT, Shen K and Lang JH: Pregnancy outcome and obstetric management after vaginal radical trachelectomy. Eur Rev Med Pharmacol Sci. 18:3019–3024. 2014.PubMed/NCBI
3	Hoenderboom BM, van Oeffelen AA, van Benthem BH, van Bergen JE, Dukers-Muijrers NH, Götz HM, Hoebe CJ, Hogewoning AA, van der Klis FR, van Baarle D, et al: The Netherlands Chlamydia cohort study (NECCST) protocol to assess the risk of late complications following Chlamydia trachomatis infection in women. BMC Infect Dis. 17:2642017. View Article : Google Scholar : PubMed/NCBI
4	Cain LR and Stulberg D: Ectopic pregnancy rates in a non-Medicaid population are lower than previously reported. Am J Obstet Gynecol. 209:5922013. View Article : Google Scholar : PubMed/NCBI
5	Akaba GO, Agida TE and Onafowokan O: Ectopic pregnancy in Nigeria's federal capital territory: A six year review. Niger J Med. 21:241–245. 2012.PubMed/NCBI
6	Senapati S and Barnhart KT: Biomarkers for ectopic pregnancy and pregnancy of unknown location. Fertil Steril. 99:1107–1116. 2013. View Article : Google Scholar : PubMed/NCBI
7	Mäkinen J: Current treatment of ectopic pregnancy. Ann Med. 31:197–201. 1999. View Article : Google Scholar : PubMed/NCBI
8	Taylor AH, Finney M, Lam PM and Konje JC: Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones. Reprod Biol Endocrinol. 9:1522011. View Article : Google Scholar : PubMed/NCBI
9	Gevaert O, De Smet F, Kirk E, Van Calster B, Bourne T, Van Huffel S, Moreau Y, Timmerman D, De Moor B and Condous G: Predicting the outcome of pregnancies of unknown location: Bayesian networks with expert prior information compared to logistic regression. Hum Reprod. 21:1824–1831. 2006. View Article : Google Scholar : PubMed/NCBI
10	Goksedef BP, Kef S, Akca A, Bayik RN and Cetin A: Risk factors for rupture in tubal ectopic pregnancy: Definition of the clinical findings. Eur J Obstet Gynecol Reprod Biol. 154:96–99. 2011. View Article : Google Scholar : PubMed/NCBI
11	van Mello NM, Mol F, Ankum WM, Mol BW, van der Veen F and Hajenius PJ: Ectopic pregnancy: How the diagnostic and therapeutic management has changed. Fertil Steril. 98:1066–1073. 2012. View Article : Google Scholar : PubMed/NCBI
12	van Mello NM, Mol F, Verhoeve HR, van Wely M, Adriaanse AH, Boss EA, Dijkman AB, Bayram N, Emanuel MH, Friederich J, et al: Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison. Hum Reprod. 28:60–67. 2013. View Article : Google Scholar : PubMed/NCBI
13	Reid S, Casikar I, Barnhart K and Condous G: Serum biomarkers for ectopic pregnancy diagnosis. Expert Opin Med Diagn. 6:153–165. 2012. View Article : Google Scholar : PubMed/NCBI
14	Kirk E, Papageorghiou AT, Condous G, Tan L, Bora S and Bourne T: The diagnostic effectiveness of an initial transvaginal scan in detecting ectopic pregnancy. Hum Reprod. 22:2824–2828. 2007. View Article : Google Scholar : PubMed/NCBI
15	Szabó I, Csabay L, Belics Z, Fekete T and Papp Z: Assessment of uterine circulation in ectopic pregnancy by transvaginal color Doppler. Eur J Obstet Gynecol Reprod Biol. 106:203–208. 2003. View Article : Google Scholar : PubMed/NCBI
16	Thoma ME: Early detection of ectopic pregnancy visualizing the presence of a tubal ring with ultrasonography performed by emergency physicians. Am J Emerg Med. 18:444–448. 2000. View Article : Google Scholar : PubMed/NCBI
17	Zele-Starcević L, Plecko V, Budimir A and Kalenić S: Choice of antimicrobial drug for infections caused by Chlamydia trachomatis and Chlamydophila pneumoniae. Acta Med Croatica. 58:329–333. 2004.(In Croatian). PubMed/NCBI
18	Stamatopoulos N, Casikar I, Reid S, Roy B, Branley J, Mongelli M and Condous G: Chlamydia trachomatis in fallopian tubes of women undergoing laparoscopy for ectopic pregnancy. Aust N Z J Obstet Gynaecol. 52:377–379. 2012. View Article : Google Scholar : PubMed/NCBI
19	Li C, Meng CX, Sun LL, Zhao WH, Zhang M, Zhang J and Cheng L: Reduced prevalence of chronic tubal inflammation in tubal pregnancies after levonorgestrel emergency contraception failure. Pharmacoepidemiol Drug Saf. 24:548–554. 2015. View Article : Google Scholar : PubMed/NCBI
20	Dunne EF, Chapin JB, Rietmeijer CA, Kent CK, Ellen JM, Gaydos CA, Willard NJ, Kohn R, Lloyd L, Thomas S, et al: Rate and predictors of repeat Chlamydia trachomatis infection among men. Sex Transm Dis. 35 Suppl:S40–S44. 2008. View Article : Google Scholar : PubMed/NCBI