Open Access

Impact of local administration of various doses of dexmedetomidine on ropivacaine‑induced lumbar plexus‑sciatic nerve block

  • Authors:
    • Jian Yu
    • Shiqiang Shan
    • Yu Nie
  • View Affiliations

  • Published online on: May 24, 2018     https://doi.org/10.3892/etm.2018.6218
  • Pages: 711-717
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the impact of various doses of dexmedetomidine (DEX) on ropivacaine (ROP)‑induced lumbar plexus‑sciatic nerve block (LSB). A total of 80 patients who underwent ankle surgery under LSB were divided into group R (applied with 30 ml 5% ROP), Dex1 (30 ml 0.5% ROP + 1 µg/kg DEX), Dex2 (30 ml 0.5% ROP + 1.5 µg/kg DEX) and Dex3 (30 ml 0.5% ROP + 2 µg/kg DEX), with 20 cases in each group. The onset time and duration of sensory and motor block, mean arterial pressure (MAP), heart rate (HR), oxygen saturation, Ramsay score, serum vascular endothelial growth factor (VEGF) level and adverse reactions in the four groups were observed. Results demonstrated that the durations of sensory and motor block in group R were shorter than those in groups Dex1‑3 (P<0.01), followed by the sequence of group Dex1
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yu J, Shan S and Nie Y: Impact of local administration of various doses of dexmedetomidine on ropivacaine‑induced lumbar plexus‑sciatic nerve block. Exp Ther Med 16: 711-717, 2018.
APA
Yu, J., Shan, S., & Nie, Y. (2018). Impact of local administration of various doses of dexmedetomidine on ropivacaine‑induced lumbar plexus‑sciatic nerve block. Experimental and Therapeutic Medicine, 16, 711-717. https://doi.org/10.3892/etm.2018.6218
MLA
Yu, J., Shan, S., Nie, Y."Impact of local administration of various doses of dexmedetomidine on ropivacaine‑induced lumbar plexus‑sciatic nerve block". Experimental and Therapeutic Medicine 16.2 (2018): 711-717.
Chicago
Yu, J., Shan, S., Nie, Y."Impact of local administration of various doses of dexmedetomidine on ropivacaine‑induced lumbar plexus‑sciatic nerve block". Experimental and Therapeutic Medicine 16, no. 2 (2018): 711-717. https://doi.org/10.3892/etm.2018.6218