Effects of remote ischemic post-conditioning on platelet activation of AMI patients

Qian,Yun-Xia; Dai,Ke-Sheng; Zhao,Li-Li; Yang,Xiang-Jun

doi:10.3892/etm.2018.6280

Effects of remote ischemic post-conditioning on platelet activation of AMI patients

Authors:
- Yun-Xia Qian
- Ke-Sheng Dai
- Li-Li Zhao
- Xiang-Jun Yang
View Affiliations

Affiliations: Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
Published online on: June 8, 2018 https://doi.org/10.3892/etm.2018.6280
Pages: 1273-1277
Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The recovery of ischemic myocardium blood perfusion is the main treatment option for acute myocardial infarction (AMI). However, this treatment option has multiple side effects that directly affect the quality of life of the patients. The activation of platelet function plays an important role in the occurrence, development and treatment of AMI. The aim of the present study was to analyze the effects of remote ischemic post‑conditioning on platelet activation of AMI patients with primary PCI treatment and clinical prognosis. A total of 71 patients with AMI were treated with primary percutaneous coronary intervention (PCI). They were randomly divided into control group (n=34) and observation group (n=37). The patients in the observation group were treated with remote ischemic post-conditioning. Further, flow cytometer was used to detect the platelet alpha granule membrane glycoprotein (CD62P) and the percentages of activated Ⅱb/Ⅲa (PAC-1). The maximum platelet aggregation rate induced by adenosine diphosphate (ADP) and arachidonic acid (AA) was measured by light transmittance aggrometer. The incidence of major adverse cardiac events (MACE) was compared between the two groups during the follow-up period of 6 months. The percentage of CD62P (24 h after PCI) in the observation group was significantly lower than control group (P<0.05). Further, the incidence of MACE in the observation group was also lower than that of the control group (P<0.05). Remote ischemic post‑conditioning could reduce the incidence of MACE in patients with AMI after primary PCI treatment. Moreover, the above observation may be related to the improvement of platelet CD62P activation.

View Figures

View References

1	Al Shammeri O and Garcia L: Thrombolysis in the age of primary percutaneous coronary intervention: Mini-review and meta-analysis of early PCI. Int J Health Sci (Qassim). 7:91–100. 2013. View Article : Google Scholar : PubMed/NCBI
2	Hausenloy DJ, Barrabes JA, Bøtker HE, Davidson SM, Di Lisa F, Downey J, Engstrom T, Ferdinandy P, Carbrera-Fuentes HA, Heusch G, et al: Ischaemic conditioning and targeting reperfusion injury: A 30 year voyage of discovery. Basic Res Cardiol. 111:702016. View Article : Google Scholar : PubMed/NCBI
3	Zhao XJ, Liu XL, He GX and Xu HP: Effects of single-dose atorvastatin on interleukin-6, interferon gamma, and myocardial no-reflow in a rabbit model of acute myocardial infarction and reperfusion. Braz J Med Biol Res. 47:245–251. 2014. View Article : Google Scholar : PubMed/NCBI
4	Li H, Jiang Z, Liu X and Yang Z: Higher plasma level of STIM1, OPG are correlated with stent restenosis after PCI. Int J Clin Exp Med. 8:21089–21097. 2015.PubMed/NCBI
5	Serebruany V, Malinin A, Aradi D, Kuliczkowski W, Norgard NB and Boden WE: The in vitro effects of niacin on platelet biomarkers in human volunteers. Thromb Haemost. 104:311–317. 2010. View Article : Google Scholar : PubMed/NCBI
6	Boukhris M, Bousselmi R, Tomasello SD, Elhadj ZI, Azzarelli S, Marzà F and Galassi AR: Mechanical post-conditioning in STEMI patients undergoing primary percutaneous coronary intervention. J Saudi Heart Assoc. 27:192–200. 2015. View Article : Google Scholar : PubMed/NCBI
7	Xu J, Sun S, Lu X, Hu X, Yang M and Tang W: Remote ischemic pre-and postconditioning improve postresuscitation myocardial and cerebral function in a rat model of cardiac arrest and resuscitation. Crit Care Med. 43:2053–2056. 2015. View Article : Google Scholar
8	Scalone G, Aurigemma C, Tomai F, Corvo P, Battipaglia I, Lanza GA and Crea F: Effect of pre-infarction angina on platelet reactivity in acute myocardial infarction. Int J Cardiol. 167:51–56. 2013. View Article : Google Scholar : PubMed/NCBI
9	Wang N, Wang GS, Yu HY, Mi L, Guo LJ and Gao W: Myocardial protection of remote ischemic postconditioning during primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction. Beijing Da Xue Xue Bao. 46:838–843. 2014.(In Chinese). PubMed/NCBI
10	Lavi S, DAlfonso S, Diamantouros P, Camuglia A, Garg P, Teefy P, Jablonsky G, Sridhar K and Lavi R: Remote ischemic postconditioning during percutaneous coronary interventions: Remote ischemic postconditioning-percutaneous coronary intervention randomized trial. Circ Cardiovasc Interv. 7:225–232. 2014. View Article : Google Scholar : PubMed/NCBI
11	Wei M, Xin P, Li S, Tao J, Li Y, Li J, Liu M, Li J, Zhu W and Redington AN: Repeated remote ischemic postconditioning protects against adverse left ventricular remodeling and improves survival in a rat model of myocardial infarction. Circ Res. 108:1220–1225. 2011. View Article : Google Scholar : PubMed/NCBI
12	Xiong J, Liao X, Xue FS, Yuan YJ, Wang Q and Liu JH: Remote ischemia conditioning-an endogenous cardioprotective strategy from outside the heart. Chin Med J (Engl). 124:2209–2215. 2011.PubMed/NCBI
13	Xu J, Sun S, Lu X, Hu X, Yang M and Tang W: Remote ischemic pre- and postconditioning improve postresuscitation myocardial and cerebral function in a rat model of cardiac arrest and resuscitation. Crit Care Med. 43:e12–e18. 2015. View Article : Google Scholar : PubMed/NCBI
14	Heusch G, Bøtker HE, Przyklenk K, Redington A and Yellon D: Remote ischemic conditioning. J Am Coll Cardiol. 65:177–195. 2015. View Article : Google Scholar : PubMed/NCBI
15	Battipaglia I, Scalone G, Milo M, Di Franco A, Lanza GA and Crea F: Upper arm intermittent ischaemia reduces exercise-related increase of platelet reactivity in patients with obstructive coronary artery disease. Heart. 97:1298–1303. 2011. View Article : Google Scholar : PubMed/NCBI
16	Stazi A, Scalone G, Laurito M, Milo M, Pelargonio G, Narducci ML, Parrinello R, Figliozzi S, Bencardino G, Perna F, et al: Effect of remote ischemic preconditioning on platelet activation and reactivity induced by ablation for atrial fibrillation. Circulation. 129:11–17. 2014. View Article : Google Scholar : PubMed/NCBI
17	Coller BS and Shattil SJ: The GPIIb/IIIa (integrin αIIbβ3) odyssey: A technology-driven saga of a receptor with twists, turns, and even a bend. Blood. 112:3011–3025. 2008. View Article : Google Scholar : PubMed/NCBI
18	van Werkum JW, Gerritsen WBM, Kelder JC, Hackeng CM, Ernst SM, Deneer VHM, Suttorp MJ, Rensing BJWM, Plokker HWM and Ten Berg JM: Inhibition of platelet function by abciximab or high-dose tirofiban in patients with STEMI undergoing primary PCI: A randomised trial. Neth Heart J. 15:375–381. 2007. View Article : Google Scholar : PubMed/NCBI