Open Access

Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites

Corrigendum in: /10.3892/etm.2018.6971

  • Authors:
    • Xiao Han
    • Liping An
    • Dongmei Yan
    • Hiroshi Matsuura
    • Weiguang Ding
    • Mengchuan Zhang
    • Guangyu Xu
    • Ying Sun
    • Guangxin Yuan
    • Manli Wang
    • Nanxi Zhao
    • Jingbo Sun
    • Xun Zhu
    • Peige Du
  • View Affiliations

  • Published online on: July 6, 2018     https://doi.org/10.3892/etm.2018.6422
  • Pages: 1586-1592
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study has demonstrated that P-5m octapeptide (P-5m) has therapeutic potential in metastatic human hepatocarcinoma, possibly through the modulation of matrix metalloproteinase‑2 expression. The purpose of the present study was to evaluate the antitumor effect of P‑5m combined with 5‑fluorouracil (5‑Fu) on the treatment of hepatoma 22 (H22) hepatocarcinoma malignant ascites in a mouse model. The inhibitory effect on the growth of mouse ascites tumors was monitored by measuring body weight gain, survival time, ascites volume, numbers of tumor cells, DNA synthesis and peritoneal capillary permeability analysis. The present data revealed a significant reduction in ascites volume and cell count in mice that were treated with P‑5m plus 5‑Fu. Furthermore, the median survival time in mice in the combination group was prolonged compared with the disease control group. Moreover, a significant reduction in the total H22 ascites cell count in mice from the combination group was observed when compared with the disease control group. P‑5m plus 5‑Fu was able to induce the cell cycle arrest and inhibit the peritoneal capillary permeability of the mice. To conclude, the present study indicated that P‑5m may have therapeutic potential in ascites caused by hepatocellular carcinoma.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Han X, An L, Yan D, Matsuura H, Ding W, Zhang M, Xu G, Sun Y, Yuan G, Wang M, Wang M, et al: Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971. Exp Ther Med 16: 1586-1592, 2018.
APA
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M. ... Du, P. (2018). Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971. Experimental and Therapeutic Medicine, 16, 1586-1592. https://doi.org/10.3892/etm.2018.6422
MLA
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M., Xu, G., Sun, Y., Yuan, G., Wang, M., Zhao, N., Sun, J., Zhu, X., Du, P."Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971". Experimental and Therapeutic Medicine 16.3 (2018): 1586-1592.
Chicago
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M., Xu, G., Sun, Y., Yuan, G., Wang, M., Zhao, N., Sun, J., Zhu, X., Du, P."Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1586-1592. https://doi.org/10.3892/etm.2018.6422