Characteristics of bone marrow cells in 107 patients with juvenile idiopathic arthritis: A retrospective study

Zhu,Di; Zhong,Jihua; Zhang,Yiwei; Chen,Fangyuan

doi:10.3892/etm.2018.6556

Characteristics of bone marrow cells in 107 patients with juvenile idiopathic arthritis: A retrospective study

Authors:
- Di Zhu
- Jihua Zhong
- Yiwei Zhang
- Fangyuan Chen
View Affiliations

Affiliations: Department of Hematology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China
Published online on: August 1, 2018 https://doi.org/10.3892/etm.2018.6556
Pages: 3161-3164

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Few studies to date have reported on the myelodysplastic features of children with juvenile idiopathic arthritis (JIA). Bone marrow specimens were collected from 107 patients aged from 7‑12 years who were initially diagnosed with JIA between May 2013 and October 2015. In 107 patients with JIA, bone marrow proliferation was higher than normal and hemophagocytes were more easily observed than usual. The characteristics of bone marrow cells in 107 patients with JIA were investigated and the associations of these characteristics with the disease was discussed in the present study. It was noticed that there were similar changes in the myeloid, erythropoietic and megakaryopoietic series in the majority of bone marrow specimens; the presence of hemophagocytes was also reported. The present findings suggest that JIA is associated with specific myelodysplastic changes, and that cellular immune system dysfunction and overreactive inflammatory cytokines may contribute to the development of these myelodysplastic changes in the bone marrow.

View Figures

View References

1	Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, He X, Maldonado-Cocco J, Orozco-Alcala J, Prieur AM, et al: International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: Second revision, edmonton, 2001. J Rheumatol. 31:390–392. 2004.PubMed/NCBI
2	Foeldvari I and Bidde M: Validation of the proposed ILAR classification criteria for juvenile idiopathic arthritis. International League of associations for rheumatology. J Rheumatol. 27:1069–1072. 2000.PubMed/NCBI
3	Ravelli A and Martini A: Juvenile idiopathic arthritis. Lancet. 369:767–778. 2007. View Article : Google Scholar : PubMed/NCBI
4	Peixuan and Xiufen Cheng Hu: Juvenile idiopathic arthritis and macrophage activation syndrome. J App Clin Pediatr. 24:1631–1633. 2009.
5	Petty RE, Southwood TR, Baum J, Bhettay E, Glass DN, Manners P, Maldonado-Cocco J, Suarez-Almazor M, Orozco-Alcala J and Prieur AM: Revision of the proposed classification criteria for juvenile idiopathisc arthritis: Durban, 1997. J Rheumatol. 25:1991–1994. 1998.PubMed/NCBI
6	Giancane G, Consolaro A, Lanni S, Davì S, Schiappapietra B and Ravelli A: Juvenile idiopathic arthritis: Diagnosis and treatment. Rheumatol Ther. 3:187–207. 2016. View Article : Google Scholar : PubMed/NCBI
7	Lee SH, Erber WN, Porwit A, Tomonaga M and Peterson LC: International Council for Standardization In Hematology: ICSH guidelines for the standardization of bone marrow specimens and reports. Int J Lab Hematol. 30:349–364. 2008. View Article : Google Scholar : PubMed/NCBI
8	Mellins ED, Macubas C and Grom AA: Pathogenesis of systemic juvenile idiopathic arthritis: Some answers, more questions. Nat Rev Rheumatol. 7:416–426. 2011. View Article : Google Scholar : PubMed/NCBI
9	Hadchouel M, Prieur AM and Griscelli C: Acute hemorrhagic, hepatic, and neurologic manifestations in juvenile rheumatoid arthritis: possible relationship to drugs or infection. J Pediatr. 106:561–566. 1985. View Article : Google Scholar : PubMed/NCBI
10	Grom AA: Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis? Arthritis Rheum. 50:689–698. 2004. View Article : Google Scholar : PubMed/NCBI
11	Stéphan J, Koné-Paut I, Galambrun C, Mouy R, Bader-Meunier B and Prieur A: Reactive haemophagocytic syndrome in children with inflammatory disorders. A retrospective study of 24 patients. Rheumatology (Oxford). 40:1285–1292. 2001. View Article : Google Scholar : PubMed/NCBI
12	Pringe A, Trail L, Ruperto N, Buoncompagni A, Loy A, Breda L, Martini A and Ravelli A: Macrophage activation syndrome in juvenile systemic lupus erythematosus: An under-recognized complication? Lupus. 16:587–592. 2007. View Article : Google Scholar : PubMed/NCBI
13	Parodi A, Davì S, Pringe AB, Pistorio A, Ruperto N, Magni-Manzoni S, Miettunen P, Bader-Meunier B, Espada G, Sterba G, et al: Macrophage activation syndrome in juvenile systemic lupus erythematosus: A multinational multicenter study of thirty-eight patients. Arthritis Rheum. 60:3388–3399. 2009. View Article : Google Scholar : PubMed/NCBI
14	Grom A: Macrophage activation syndrome and reactive hemophagocytic lymphohistiocytosis: The same entities? Curr Opin Rheumatol. 15:587–590. 2003. View Article : Google Scholar : PubMed/NCBI
15	Janka G: Hemophagocytic syndromes. Blood Rev. 21:245–253. 2007. View Article : Google Scholar : PubMed/NCBI
16	Sawhney S, Woo P and Murray KJ: Macrophage activation syndrome: A potentially fatal complication of rheumatic disorders. Arch Dis Child. 85:421–426. 2001. View Article : Google Scholar : PubMed/NCBI
17	Moradinejad MH and Ziaee V: The incidence of macrophage activation syndrome in children with rheumatic disorders. Minerva Pediatr. 63:459–466. 2011.PubMed/NCBI