Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation

Feng,Li; Li,Jianguo; Qin,Ling; Guo,Dan; Ding,Hongyu; Deng,Daping

doi:10.3892/etm.2018.6570

Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation

Authors:
- Li Feng
- Jianguo Li
- Ling Qin
- Dan Guo
- Hongyu Ding
- Daping Deng
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Affiliations: Ultrasound Department, Qianfoshan Hospital of Shandong Province, Jinan, Shandong 250014, P.R. China, Department of Human Anatomy, The School of Medicine of Inner Mongolia University for The Nationalities, Tongliao, Inner Mongolia 028041, P.R. China, Clinical Medicine Department, Taishan Medical University, Taian, Shandong 271016, P.R. China, Laboratory of Radiation Biology, The Radiation Medical Institute, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, P.R. China
Published online on: August 3, 2018 https://doi.org/10.3892/etm.2018.6570
Pages: 3143-3148

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Abstract

The radioprotective effect of lactoferrin (LF) was studied in mice subjected to sublethal X‑ray irradiation. The mice were randomly divided into the Control (non‑irradiated mice fed a standard diet without LF), IR (irradiated mice fed a standard diet) and IR+LF (irradiated mice fed LF) groups. The mice were fed daily for 7 days prior to irradiation and for 30 continuous days following irradiation. The survival ratio of the mice in the IR+LF group was significantly increased compared with the IR group between days 15 and 30 after irradiation. The body weight of the mice in the IR+LF group was increased compared with the IR group, and the difference was statistically significant. Blood was collected from the mice via the tail vein on days 2, 7, 14, 21 and 30 following irradiation. The laboratory indicators, including leukocyte, erythrocyte and platelet counts recovered more rapidly following irradiation in the IR+LF group compared with the IR group. Treatment of the irradiated mice with LF significantly reduced the DNA damage. In the hepatic tissue the level of superoxide dismutase in the IR+LF group was significantly increased, while malondialdehyde was significantly decreased compared with the IR group. These findings indicate that LF may prevent radiation damage and may have potential as a treatment for patients with cancer who receive radiotherapy.

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