Open Access

Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI

  • Authors:
    • Qifeng Zhang
    • Zhixiong Zhong
    • Bin Li
    • Zhengxian Liao
    • Pingsen Zhao
    • Zhuolian Ye
    • Xuebo He
    • Hao Wang
    • Wenhao Chen
    • Junping Huang
  • View Affiliations

  • Published online on: August 22, 2018     https://doi.org/10.3892/etm.2018.6650
  • Pages: 3492-3496
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effects of different cytochrome P450 2C19 (CYP2C19) genotypes on the prognosis of clopidogrel resistance in patients complicated with atrial fibrillation taking clopidogrel after percutaneous coronary intervention (PCI) were investigated. Eighty patients who were complicated with atrial fibrillation and treated with clopidogrel antiplatelet therapy after PCI in Meizhou Hospital Affiliated to Zhongshan University from September 2015 to January 2017 were selected, and divided into two groups according to the CYP2C19 genotype: extensive metabolism (EM) group and poor metabolism (PM) group. The related risk factors of clopidogrel resistance were determined, and the platelet aggregation rate and clopidogrel resistance rate were compared between the two groups during treatment. Non-fatal myocardial infarction and serious life-threatening complications in the two groups were observed. The increased total cholesterol level and the history of smoking and drinking were the independent risk factors of atrial fibrillation after PCI. The platelet aggregation rates in the EM group at 1, 3 and 12 months after medication were significantly lower than those in the PM group in the same period (P<0.05). The clopidogrel resistance rates in EM group before medication and at 1, 3 and 12 months after medication were higher than those in PM group in the same period (P<0.05). The onset time of non-fatal myocardial infarction in EM group was earlier than that in PM group (P<0.05), the infarct area was larger than that in PM group (P<0.05), and the left ventricular ejection fraction (EF) after onset was lower than that in PM group (P<0.05). In conclusion, the increased total cholesterol level and the history of smoking and drinking are the independent risk factors of clopidogrel resistance in patients complicated with atrial fibrillation after PCI. The incidence rates of cardiac complications are increased significantly in patients with PM CYP2C19 genotype.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang Q, Zhong Z, Li B, Liao Z, Zhao P, Ye Z, He X, Wang H, Chen W, Huang J, Huang J, et al: Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI. Exp Ther Med 16: 3492-3496, 2018.
APA
Zhang, Q., Zhong, Z., Li, B., Liao, Z., Zhao, P., Ye, Z. ... Huang, J. (2018). Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI. Experimental and Therapeutic Medicine, 16, 3492-3496. https://doi.org/10.3892/etm.2018.6650
MLA
Zhang, Q., Zhong, Z., Li, B., Liao, Z., Zhao, P., Ye, Z., He, X., Wang, H., Chen, W., Huang, J."Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI". Experimental and Therapeutic Medicine 16.4 (2018): 3492-3496.
Chicago
Zhang, Q., Zhong, Z., Li, B., Liao, Z., Zhao, P., Ye, Z., He, X., Wang, H., Chen, W., Huang, J."Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3492-3496. https://doi.org/10.3892/etm.2018.6650