Expression of tissue factor in human cervical carcinoma tissue

Zhao,Xitong; Cheng,Chu; Gou,Jinhai; Yi,Tao; Qian,Yanping; Du,Xue; Zhao,Xia

doi:10.3892/etm.2018.6723

Expression of tissue factor in human cervical carcinoma tissue

Authors:
- Xitong Zhao
- Chu Cheng
- Jinhai Gou
- Tao Yi
- Yanping Qian
- Xue Du
- Xia Zhao
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Affiliations: Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics and Gynecology and Pediatric Diseases and Birth Defects, The Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Published online on: September 11, 2018 https://doi.org/10.3892/etm.2018.6723
Pages: 4075-4081
Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate tissue factor (TF) expression in cervical cancer and explore its association with disease progression. A total of 258 cervical cancer tissues and their adjacent normal tissues were collected between September 2014 and September 2016. TF expression was detected in the tissue samples by immunohistochemistry and western blot analysis. Associations between the expression of TF and clinical stage, differentiation status and metastasis of cancer cells were examined. The mean immunohistochemistry score of TF expression in cervical cancer tissues was 2.86±1.76, which was significantly increased compared with the adjacent normal tissues (0.28±0.45). The expression of TF was also significantly associated with the clinical stage, lymph node metastasis and distant metastasis of cancer cells. Immunohistochemistry staining and western blot analysis demonstrated that TF expression in cervical cancer tissues significantly increased as the clinical stage increased. TF expression in tumor tissues from patients with lymph node metastasis was significantly increased compared with samples from patients without lymph node metastasis. TF expression was also significantly increased in patients with distant metastasis compared with those without. In conclusion, TF is highly expressed in cervical cancer tissues and high expression of TF may enhance the invasion and metastasis of cervical cancer cells.

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