Human umbilical cord‑derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice

Yan,Nannan; Xu,Jie; Zhao,Chuanxiang; Wu,Yi; Gao,Fengwei; Li,Ci; Zhou,Wenhui; Xiao,Tengfei; Zhou,Xiaoming; Shao,Qixiang; Xia,Sheng

doi:10.3892/etm.2018.6763

Human umbilical cord‑derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice

Authors:
- Nannan Yan
- Jie Xu
- Chuanxiang Zhao
- Yi Wu
- Fengwei Gao
- Ci Li
- Wenhui Zhou
- Tengfei Xiao
- Xiaoming Zhou
- Qixiang Shao
- Sheng Xia
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Affiliations: Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China, Department of Pathology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China
Published online on: September 19, 2018 https://doi.org/10.3892/etm.2018.6763
Pages: 4445-4456
Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord‑derived mesenchymal stem cells (hUC‑MSCs) exhibit similar immune regulatory properties to bone marrow‑derived MSCs. hUC‑MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. The current study aimed to investigate potential antiallergic properties of hUC‑MSCs in mice with ovalbumin (OVA)‑induced food allergy. Administration of hUC‑MSCs cells intraperitoneally combined with oral gavage of the culture medium significantly alleviated OVA‑induced diarrhea symptoms. Additionally, this treatment significantly decreased IgE levels and the percentage of T helper 2 cells in the blood, which were increased in mice with OVA‑induced food allergy. The mRNA levels of the inflammatory cytokines interleukin‑4 and tumor necrosis factor‑α, and inflammatory cell infiltration in mouse colons were significantly decreased in hUC‑MSCs‑treated animals compared with mice with OVA‑induced food allergy. Goblet cells were detected in colons of allergy‑induced mice and their numbers were reduced following treatment with hUC‑MSCs. In addition, treatment with hUC‑MSCs reestablished the gut flora. The results revealed that hUC‑MSCs may have a potential application in food allergy therapy.

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