Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma

Wang,Guan‑Nan; Cui,Yong; Zhao,Wu‑Gan; Li,Ling; Zhang,Xu‑Dong; Chang,Yu; Gao,Xian‑Zheng; Li,Ye; Zhang,Ming‑Zhi; Li,Wen‑Cai

doi:10.3892/etm.2018.6768

Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma

Authors:
- Guan‑Nan Wang
- Yong Cui
- Wu‑Gan Zhao
- Ling Li
- Xu‑Dong Zhang
- Yu Chang
- Xian‑Zheng Gao
- Ye Li
- Ming‑Zhi Zhang
- Wen‑Cai Li
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Affiliations: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Urology, The First Affiliated Hospital of Henan University of TCM, Zhengzhou, Henan 450052, P.R. China, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: September 19, 2018 https://doi.org/10.3892/etm.2018.6768
Pages: 4772-4778

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Abstract

Hydroa vacciniforme‑like lymphoproliferative disorder (HVLPD) is defined as a distinctive clinicopathological type of cutaneous lymphoma and a subset of patients with this disease exhibit the natural killer (NK)‑cell phenotype. The HVLPD‑NK cell phenotype may be difficult to distinguish from cutaneous natural killer T‑cell lymphoma (CNKTL), as these two diseases share similar immunophenotypic markers. Therefore, the aim of the present study was to analyze the clinicopathological features of this rare disease and compare these features with those of CNKTL. The clinical, histopathological and molecular features of 5 patients with the HVLPD‑NK cell phenotype and 11 patients with CNKTL were evaluated. As well as certain subtle histopathological differences, there marked differences the age, distribution of lesions and clinical course differed between patients with these two diseases. These results suggest that the HVLPD‑NK cell phenotype should be classified as a separate disorder and treated accordingly.

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1	Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Thiele Jurgen HS and Vardiman JW: World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues. 4th. IARC Press; Lyon: 2008
2	Cho KH, Kim CW, Heo DS, Lee DS, Choi WW, Rim JH and Han WS: Epstein-Barr virus-associated peripheral T-cell lymphoma in adults with hydroa vacciniforme-like lesions. Clin Exp Dermatol. 26:242–247. 2001. View Article : Google Scholar : PubMed/NCBI
3	Feng S, Jin P and Zeng X: Hydroa vacciniforme-like primary cutaneous CD8-positive T-cell lymphoma. Eur J Dermatol. 18:364–365. 2008.PubMed/NCBI
4	Magaña M, Sangüeza P, Gil-Beristain J, Sánchez-Sosa S, Salgado A, Ramón G and Sangüeza OP: Angiocentric cutaneous T-cell lymphoma of childhood (hydroa-like lymphoma): A distinctive type of cutaneous T-cell lymphoma. J Am Acad Dermatol. 38:574–579. 1998. View Article : Google Scholar : PubMed/NCBI
5	Barrionuevo C, Anderson VM, Zevallos-Giampietri E, Zaharia M, Misad O, Bravo F, Cáceres H, Taxa L, Martínez MT, Wachtel A and Piris MA: Hydroa-like cutaneous T-cell lymphoma: A clinicopathologic and molecular genetic study of 16 pediatric cases from Peru. Appl Immunohistochem Mol Morphol. 10:7–14. 2002. View Article : Google Scholar : PubMed/NCBI
6	Xu Z and Lian S: Epstein-Barr virus-associated hydroa vacciniforme-like cutaneous lymphoma in seven Chinese children. Pediatr Dermatol. 27:463–469. 2010. View Article : Google Scholar : PubMed/NCBI
7	Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD and Jaffe ES: The 2016 revision of the World Health Organization (WHO) classification of lymphoid neoplasms. Blood. 127:2375–2390. 2016. View Article : Google Scholar : PubMed/NCBI
8	Iwatsuki K, Ohtsuka M, Akiba H and Kaneko F: Atypical hydroa vacciniforme in childhood: From a smoldering stage to Epstein-Barr virus-associated lymphoid malignancy. J Am Acad Dermatol. 40:283–284. 1999. View Article : Google Scholar : PubMed/NCBI
9	Iwatsuki K, Satoh M, Yamamoto T, Oono T, Morizane S, Ohtsuka M, Xu ZG, Suzuki D and Tsuji K: Pathogenic link between hydroa vacciniforme and Epstein-Barr virus-associated hematologic disorders. Arch Dermatol. 142:587–595. 2006. View Article : Google Scholar : PubMed/NCBI
10	Doeden K, Molina-Kirsch H, Perez E, Warnke R and Sundram U: Hydroa-like lymphoma with CD56 expression. J Cutan Pathol. 35:488–494. 2008. View Article : Google Scholar : PubMed/NCBI
11	Rodriguez-pinilla SM, Barrionuevo C, Garcia J, Martínez MT, Pajares R, Montes-Moreno S, Casavilca S, Montes J, Bravo F, Zaharia M, et al: EBV-associated cutaneous NK/T-cell lymphoma: Review of a series of 14 cases from Peru in children and young adults. Am J Surg Pathol. 34:1773–1782. 2010. View Article : Google Scholar : PubMed/NCBI
12	Quintanilla-Martínez L, Ridaura C, Nagl F, Sáez-de-Ocariz M, Durán-McKinster C, Ruiz-Maldonado R, Alderete G, Grube P, Lome-Maldonado C, Bonzheim I and Fend F: Hydroa vacciniforme like lymphoma: A chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma. Blood. 122:3101–3110. 2013. View Article : Google Scholar : PubMed/NCBI
13	Santos M, Nogueira L, Talahri C, Massone C, Cerroni L, Mira MT and Talhari S: Hydroavacciniforme-like lymphoma in a patient from the Brazilian Amazon. Int J Dermatol. 52:641–643. 2013. View Article : Google Scholar : PubMed/NCBI
14	Magaña M, Massone C, Magaña P and Cerroni L: Clinicopathologic features of hydroa vacciniforme-like lymphoma: A series of 9 patients. Am J Dermato pathol. 38:20–25. 2016. View Article : Google Scholar
15	Patel KP, Pan Q, Wang Y, Maitta RW, Du J, Xue X, Lin J and Ratech H: Comparison of BIOMED-2 versus laboratory-developed polymerase chain reaction assays for detecting T-cell receptor-gamma gene rearrangements. J Mol Diagn. 12:226–237. 2010. View Article : Google Scholar : PubMed/NCBI
16	Mraz-Gernhard S, Natkunam Y, Hoppe RT, LeBoit P, Kohler S and Kim YH: Natural killer/natural killer-like T-cell lymphoma, CD56+, presenting in the skin: An increasingly recognized entity with an aggressive course. J Clin Oncol. 19:2179–2188. 2001. View Article : Google Scholar : PubMed/NCBI
17	Child FJ, Mitchell TJ, Whittaker SJ, Calonje E, Spittle M, Crocker J and Russell-Jones R: Blastic natural killer cell and extranodal natural killer cell-like T-cell lymphoma presenting in the skin: Report of six cases from the UK. Br J Dermatol. 148:507–515. 2003. View Article : Google Scholar : PubMed/NCBI
18	Yu JB, Zuo Z, Tang Y, Zhao S, Zhang YC, Bi CF, Wang WY, Zhang WY, Wang L and Liu WP: Extranodal nasal-type natural killer/T-cell lymphoma of the skin: A clinicopathologic study of 16 cases in China. Hum Pathol. 40:807–816. 2009. View Article : Google Scholar : PubMed/NCBI
19	Takata K, Hong ME, Sitthinamsuwan P, Loong F, Tan SY, Liau JY, Hsieh PP, Ng SB, Yang SF, Pongpruttipan T, et al: Primary cutaneous NK/T-cell lymphoma, nasal type and CD56-positive peripheral T-cell lymphoma: A cellular lineage and clinicopathologic study of 60 patients from Asia. Am J Surg Pathol. 39:1–12. 2015. View Article : Google Scholar : PubMed/NCBI
20	Hsi AC1 and Rosman IS: Histopathology of cutaneous inflammatory disorders in children. Pediatr Dev Pathol. 21:115–149. 2018. View Article : Google Scholar : PubMed/NCBI
21	Sangueza M and Plaza JA: Hydroa vacciniforme-like cutaneous T-cell lymphoma: Clinicopathologic and immunohistochemical study of 12 cases. J Am Acad Dermatol. 69:112–119. 2013. View Article : Google Scholar : PubMed/NCBI
22	Yang YQ, Fan L, Wang L, Xu J, Zhang R, Ge Z, Li JY and Xu W: Systemic lymphoma arising from hydroa vacciniforme-like lymphoma: Report of two cases with review of literature. Int J Clin Exp Pathol. 7:6403–6408. 2014.PubMed/NCBI